Johns Josephine M, Elliott Deborah L, Hofler Vivian E, Joyner Paul W, McMurray Matthew S, Jarrett Thomas M, Haslup Amber M, Middleton Christopher L, Elliott Jay C, Walker Cheryl H
Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Behav Neurosci. 2005 Dec;119(6):1605-18. doi: 10.1037/0735-7044.119.6.1605.
The link between impaired maternal behavior (MB) and cocaine treatment could result from drug-induced decreases in maternal reactivity to offspring, prenatal drug exposure (PDE) in offspring that could alter their ability to elicit MB, or the interaction of both, which could subsequently impair MB of the 1st-generation dams. Following chronic or intermittent cocaine or saline treatment during gestation, rat dams rearing natural or cross-fostered litters were compared along with untreated dams for MB. Untreated 1st-generation females with differentially treated rearing dams and PDE were tested for MB with their natural litters. The authors report disruptions in MB in dams and their 1st-generation offspring, attributable to main and interaction effects of maternal treatment, litter PDE, and rearing experience.
母体行为受损（MB）与可卡因治疗之间的联系可能源于药物导致母体对后代反应性降低、后代的产前药物暴露（PDE）可能改变其引发母体行为的能力，或者两者相互作用，这随后可能损害第一代母鼠的母体行为。在妊娠期进行慢性或间歇性可卡因或生理盐水治疗后，将饲养自然或交叉寄养幼崽的母鼠与未治疗的母鼠进行母体行为比较。对具有不同处理的饲养母鼠和PDE的未处理第一代雌性进行测试，观察它们与自然幼崽之间的母体行为。作者报告称，母鼠及其第一代后代的母体行为受到干扰，这归因于母体治疗、幼崽PDE和饲养经验的主要及相互作用效应。
