可卡因治疗与产前环境相互作用，扰乱大鼠的代际母性行为。
Cocaine treatment and prenatal environment interact to disrupt intergenerational maternal behavior in rats.
作者信息
Johns Josephine M, Elliott Deborah L, Hofler Vivian E, Joyner Paul W, McMurray Matthew S, Jarrett Thomas M, Haslup Amber M, Middleton Christopher L, Elliott Jay C, Walker Cheryl H
机构信息
Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
出版信息
Behav Neurosci. 2005 Dec;119(6):1605-18. doi: 10.1037/0735-7044.119.6.1605.
Abstract
The link between impaired maternal behavior (MB) and cocaine treatment could result from drug-induced decreases in maternal reactivity to offspring, prenatal drug exposure (PDE) in offspring that could alter their ability to elicit MB, or the interaction of both, which could subsequently impair MB of the 1st-generation dams. Following chronic or intermittent cocaine or saline treatment during gestation, rat dams rearing natural or cross-fostered litters were compared along with untreated dams for MB. Untreated 1st-generation females with differentially treated rearing dams and PDE were tested for MB with their natural litters. The authors report disruptions in MB in dams and their 1st-generation offspring, attributable to main and interaction effects of maternal treatment, litter PDE, and rearing experience.
摘要
母体行为受损（MB）与可卡因治疗之间的联系可能源于药物导致母体对后代反应性降低、后代的产前药物暴露（PDE）可能改变其引发母体行为的能力，或者两者相互作用，这随后可能损害第一代母鼠的母体行为。在妊娠期进行慢性或间歇性可卡因或生理盐水治疗后，将饲养自然或交叉寄养幼崽的母鼠与未治疗的母鼠进行母体行为比较。对具有不同处理的饲养母鼠和PDE的未处理第一代雌性进行测试，观察它们与自然幼崽之间的母体行为。作者报告称，母鼠及其第一代后代的母体行为受到干扰，这归因于母体治疗、幼崽PDE和饲养经验的主要及相互作用效应。
相似文献
1
Cocaine treatment and prenatal environment interact to disrupt intergenerational maternal behavior in rats.可卡因治疗与产前环境相互作用，扰乱大鼠的代际母性行为。
Behav Neurosci. 2005 Dec;119(6):1605-18. doi: 10.1037/0735-7044.119.6.1605.
2
Cocaine disrupts pup-induced maternal behavior in juvenile and adult rats.可卡因会扰乱幼年和成年大鼠中幼崽诱导的母性行为。
Neurotoxicol Teratol. 2007 Nov-Dec;29(6):634-41. doi: 10.1016/j.ntt.2007.07.003. Epub 2007 Jul 14.
3
Intergenerational effects of cocaine on maternal aggressive behavior and brain oxytocin in rat dams.可卡因对大鼠母代攻击行为及脑内催产素的代际影响。
Stress. 2008 Sep;11(5):398-410. doi: 10.1080/10253890701850239.
4
Foster mother care but not prenatal morphine exposure enhances cocaine self-administration in young adult male and female rats.养母照顾而非产前吗啡暴露会增强年轻成年雄性和雌性大鼠的可卡因自我给药行为。
Dev Psychobiol. 2007 Jul;49(5):463-73. doi: 10.1002/dev.20240.
5
Impact of gestational cocaine treatment or prenatal cocaine exposure on early postpartum oxytocin mRNA levels and receptor binding in the rat.孕期可卡因处理或产前可卡因暴露对大鼠产后早期催产素mRNA水平及受体结合的影响。
Neuropeptides. 2008 Oct-Dec;42(5-6):641-52. doi: 10.1016/j.npep.2008.05.003. Epub 2008 Jun 24.
6
Gestational ethanol and nicotine exposure: effects on maternal behavior, oxytocin, and offspring ethanol intake in the rat.孕期乙醇和尼古丁暴露：对大鼠母体行为、催产素及子代乙醇摄入量的影响。
Neurotoxicol Teratol. 2008 Nov-Dec;30(6):475-86. doi: 10.1016/j.ntt.2008.07.001. Epub 2008 Jul 11.
7
Early postpartum pup preference is altered by gestational cocaine treatment: associations with infant cues and oxytocin expression in the MPOA.孕期可卡因治疗会改变产后早期的幼崽偏好：与婴儿线索及视前区室旁核中催产素表达的关联。
Behav Brain Res. 2015 Feb 1;278:176-85. doi: 10.1016/j.bbr.2014.09.045. Epub 2014 Oct 6.
8
Intravenous gestational cocaine in rats: effects on offspring development and weanling behavior.大鼠静脉注射孕期可卡因：对后代发育和断奶期行为的影响。
Neurotoxicol Teratol. 1993 Sep-Oct;15(5):335-44. doi: 10.1016/0892-0362(93)90035-m.
9
Prenatal cocaine but not prenatal malnutrition affects foster mother-pup interactions in rats.产前可卡因暴露而非产前营养不良会影响大鼠中养母与幼崽间的互动。
Neurotoxicol Teratol. 1995 Sep-Oct;17(5):601-8. doi: 10.1016/0892-0362(95)00021-i.
10
A fostering study of the effects of prenatal cocaine exposure: I. Maternal behaviors.一项关于产前可卡因暴露影响的寄养研究：I. 母亲行为。
Neurotoxicol Teratol. 1992 Nov-Dec;14(6):415-21. doi: 10.1016/0892-0362(92)90052-c.
引用本文的文献
1
Ontogenic, Immunological, and Behavioral Changes of Crack Cocaine Exposure During the Gestational Period.孕期接触快克可卡因的个体发生、免疫学及行为变化
Mol Neurobiol. 2025 May 16. doi: 10.1007/s12035-025-05004-2.
2
Use of fast-scan cyclic voltammetry to assess phasic dopamine release in rat models of early postpartum maternal behavior and neglect.使用快速扫描循环伏安法评估产后早期母性行为和忽视大鼠模型中的阶段性多巴胺释放。
Behav Pharmacol. 2017 Dec;28(8):648-660. doi: 10.1097/FBP.0000000000000347.
3
Prenatal substance exposure and child self-regulation: Pathways to risk and protection.产前物质暴露与儿童自我调节：风险与保护途径
J Exp Child Psychol. 2015 Sep;137:12-29. doi: 10.1016/j.jecp.2015.02.007. Epub 2015 Apr 24.
4
Effects of prenatal cocaine exposure on early postnatal rodent brain structure and diffusion properties.产前接触可卡因对出生后早期啮齿动物脑结构和扩散特性的影响。
Neurotoxicol Teratol. 2015 Jan-Feb;47:80-8. doi: 10.1016/j.ntt.2014.11.007. Epub 2014 Nov 22.
5
Early postpartum pup preference is altered by gestational cocaine treatment: associations with infant cues and oxytocin expression in the MPOA.孕期可卡因治疗会改变产后早期的幼崽偏好：与婴儿线索及视前区室旁核中催产素表达的关联。
Behav Brain Res. 2015 Feb 1;278:176-85. doi: 10.1016/j.bbr.2014.09.045. Epub 2014 Oct 6.
6
Prenatal cocaine exposure and trajectories of externalizing behavior problems in early childhood: examining the role of maternal negative affect.产前可卡因暴露与儿童早期外化行为问题的轨迹：检验母亲消极情绪的作用。
Dev Psychopathol. 2014 May;26(2):515-28. doi: 10.1017/S0954579414000091. Epub 2014 Mar 12.
7
Effect of prenatal cocaine on early postnatal thermoregulation and ultrasonic vocalization production.产前可卡因对早期产后体温调节和超声发声产生的影响。
Front Psychol. 2013 Nov 26;4:882. doi: 10.3389/fpsyg.2013.00882. eCollection 2013.
8
Prenatal and gestational cocaine exposure: Effects on the oxytocin system and social behavior with implications for addiction.产前和妊娠期可卡因暴露：对催产素系统和社会行为的影响及其与成瘾的关系。
Pharmacol Biochem Behav. 2014 Apr;119:10-21. doi: 10.1016/j.pbb.2013.07.004. Epub 2013 Jul 21.
9
Effects of cocaine on maternal behavior and neurochemistry.可卡因对母婴行为和神经化学的影响。
Curr Neuropharmacol. 2012 Mar;10(1):53-63. doi: 10.2174/157015912799362760.
10
Variations in the nature of behavioral experience can differentially alter the consequences of developmental exposures to lead, prenatal stress, and the combination.行为体验性质的变化会不同程度地改变儿童期接触铅、产前应激以及两者结合的发展后果。
Toxicol Sci. 2013 Jan;131(1):194-205. doi: 10.1093/toxsci/kfs260. Epub 2012 Aug 28.
本文引用的文献
1
An oxytocin antagonist infused into the central nucleus of the amygdala increases maternal aggressive behavior.注入杏仁核中央核的催产素拮抗剂会增加母性行为的攻击性。
Behav Neurosci. 2003 Apr;117(2):195-201. doi: 10.1037/0735-7044.117.2.195.
2
Oxytocin links mothering received, mothering bestowed and adult stress responses.催产素将所接受的母爱、给予的母爱与成年后的应激反应联系起来。
Stress. 2002 Dec;5(4):259-67. doi: 10.1080/1025389021000037586.
3
Cocaine and development: a retrospective perspective.可卡因与发育：回顾性视角
Neurotoxicol Teratol. 2002 May-Jun;24(3):321-7. doi: 10.1016/s0892-0362(02)00194-0.
4
Naturally occurring variations in maternal behavior in the rat are associated with differences in estrogen-inducible central oxytocin receptors.大鼠母体行为中自然发生的变异与雌激素诱导的中枢催产素受体的差异有关。
Proc Natl Acad Sci U S A. 2001 Oct 23;98(22):12736-41. doi: 10.1073/pnas.221224598. Epub 2001 Oct 16.
5
Dose-related effects of chronic gestational cocaine treatment on maternal aggression in rats on postpartum days 2, 3, and 5.慢性孕期可卡因处理对产后第2、3和5天大鼠母性行为的剂量相关影响。
Prog Neuropsychopharmacol Biol Psychiatry. 2001 Oct;25(7):1403-20. doi: 10.1016/s0278-5846(01)00197-x.
6
Brief vs. long maternal separations in infancy: contrasting relationships with adult maternal behavior and lactation levels of aggression and anxiety.婴儿期短暂与长期母婴分离：与成年期母性行为以及攻击和焦虑泌乳水平的对比关系。
Psychoneuroendocrinology. 2001 Oct;26(7):657-72. doi: 10.1016/s0306-4530(01)00019-1.
7
Enduring effects of prenatal cocaine administration on emotional behavior in rats.产前给予可卡因对大鼠情绪行为的持久影响。
Physiol Behav. 2000;70(1-2):149-56. doi: 10.1016/s0031-9384(00)00245-6.
8
Influence of neonatal rearing conditions on stress-induced adrenocorticotropin responses and norepinepherine release in the hypothalamic paraventricular nucleus.新生期饲养条件对下丘脑室旁核应激诱导的促肾上腺皮质激素反应及去甲肾上腺素释放的影响。
J Neuroendocrinol. 2000 Jan;12(1):5-12. doi: 10.1046/j.1365-2826.2000.00422.x.
9
Nongenomic transmission across generations of maternal behavior and stress responses in the rat.大鼠母体行为和应激反应的跨代非基因组传递。
Science. 1999 Nov 5;286(5442):1155-8. doi: 10.1126/science.286.5442.1155.
10
Dose-dependent effects of multiple acute cocaine injections on maternal behavior and aggression in Sprague-Dawley rats.多次急性注射可卡因对斯普拉格-道利大鼠母性行为和攻击性的剂量依赖性影响。
Dev Neurosci. 1998;20(6):525-32. doi: 10.1159/000017353.
Zotero 插件