Social and sexual motivation in the mouse.

Does a sexual encounter have reward value for a learned operant response? Ovariectomized female mice with or without estradiol replacement were trained to perform a bar-contact operant response for either male or female targets. Response rates of females with estradiol replacement did not differ from those of females without estradiol replacement or females responding for access to females. Reflexive receptive sexual behavior remained responsive to estradiol replacement. Experiment 2 demonstrated that socially isolated females would respond faster for access to a female target than when group housed. Finally, the oxytocin blocker, atosiban, reduced both operant and reflexive social behavior. These results converge on the conclusion that the operant reward value of social and sexual contact is primarily social.