Vann Seralynne D, Aggleton John P
School of Psychology, Cardiff University, Cardiff, United Kingdom.
Behav Neurosci. 2005 Dec;119(6):1682-6. doi: 10.1037/0735-7044.119.6.1682.
The present study provides the 1st report on the effects of selective lesions of the dysgranular portion of the retrosplenial cortex in rats. Excitotoxic lesions of the dysgranular area were sufficient to impair behavior in the radial-arm maze by biasing the strategy used to solve the task. In particular, rats with dysgranular retrosplenial lesions were less reliant on distal visual cues to control performance of a working memory task in the radial-arm maze. Instead, they were more reliant on using a motor turning strategy to solve the task. This change in strategy is consistent with anatomical data showing that the dysgranular region is the primary recipient of visual inputs to the rat retrosplenial cortex.
本研究首次报告了选择性损伤大鼠压后皮质颗粒下部分的影响。颗粒下区域的兴奋性毒性损伤足以通过使解决任务所采用的策略产生偏差来损害放射状臂迷宫中的行为。具体而言，压后皮质颗粒下损伤的大鼠在放射状臂迷宫中控制工作记忆任务表现时，对远端视觉线索的依赖程度较低。相反，它们更依赖使用运动转向策略来解决任务。这种策略变化与解剖学数据一致，该数据表明颗粒下区域是大鼠压后皮质视觉输入的主要接受者。
