HIV-1感染的非洲儿童中nef基因序列变异
nef gene sequence variation among HIV-1-infected African children.
作者信息
Chakraborty R, Reinis M, Rostron T, Philpott S, Dong T, D'Agostino A, Musoke R, Silva E, Stumpf M, Weiser B, Burger H, Rowland-Jones S L
机构信息
Nyumbani Children's Home, Nairobi, Kenya.
出版信息
HIV Med. 2006 Mar;7(2):75-84. doi: 10.1111/j.1468-1293.2006.00341.x.
BACKGROUND
There are few data on African children infected with nonclade B HIV-1 in endemic settings, which limits generalizations about pathogenesis and progression. Genotypic and phenotypic variations in host immunogenetics and HIV-1 negative factor (nef) accessory protein may influence disease progression and have frequently been characterized in subjects infected with clade B HIV-1.
METHODS
In this descriptive study, we report nef gene sequence variation and host genetic polymorphisms in 32 Kenyan children, including 12 slow progressors.
RESULTS
Phylogenetic analysis identified HIV-1 clades A, C and D and a recombinant A/D subtype. Grossly defective nef genes or significant changes from relevant clade reference sequences were not identified in children with delayed disease progression.
CONCLUSIONS
nef sequence variations may not be common in perinatally infected African children. Further studies are warranted in HIV-1-infected subjects in settings where infection is endemic.
背景
在艾滋病流行地区，关于感染非B亚型HIV-1的非洲儿童的数据很少，这限制了对发病机制和疾病进展的概括。宿主免疫遗传学和HIV-1负因子（nef）辅助蛋白的基因型和表型变异可能影响疾病进展，并且在感染B亚型HIV-1的受试者中经常被描述。
方法
在这项描述性研究中，我们报告了32名肯尼亚儿童的nef基因序列变异和宿主基因多态性，其中包括12名疾病进展缓慢者。
结果
系统发育分析确定了HIV-1的A、C和D亚型以及一种重组A/D亚型。在疾病进展延迟的儿童中未发现严重缺陷的nef基因或与相关亚型参考序列的显著变化。
结论
nef序列变异在围产期感染的非洲儿童中可能并不常见。在艾滋病流行地区的HIV-1感染者中进行进一步研究是必要的。
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