Persson K, Carlsson A, Hambleton C, Guidry A J
Department of Obstetrics and Gynaecology, Swedish University of Agricultural Sciences, Uppsala.
Zentralbl Veterinarmed B. 1992 May;39(3):165-74. doi: 10.1111/j.1439-0450.1992.tb01154.x.
Immunoglobulins (Ig) and antibacterial proteins like lysozyme and lactoferrin are components of the humoral defence against infections. Changes in Ig, lysozyme and lactoferrin concentrations during endotoxin-induced inflammation in the test cistern and udder quarter of the dry cow were studied. Surgical closure of the passage between teat and udder cisterns enabled studies of reactions in the teat cistern without interference of the mammary gland. After endotoxin infusion, IgG1, IgG2, lysozyme, and to some extent IgM, increased in the teats and udder quarters, and were positively correlated with changes in somatic cell counts. No significant changes were observed in IgA or lactoferrin. The origin and significance of Ig, lysozyme and lactoferrin in the bovine teat and udder are discussed. Ig probably originated both from serum and from local plasma cells, while leukocytes appeared to be the source of lysozyme during inflammation. Secretory epithelium appeared to be the source of lactoferrin. Support for this theory was the almost total absence of lactoferrin in teat cistern samples.
免疫球蛋白（Ig）以及诸如溶菌酶和乳铁蛋白等抗菌蛋白是体液抗感染防御的组成部分。研究了干奶牛的试验乳池和乳房象限在内毒素诱导的炎症过程中Ig、溶菌酶和乳铁蛋白浓度的变化。手术封闭乳头与乳房乳池之间的通道，使得能够在不受到乳腺干扰的情况下研究乳头乳池中的反应。在内毒素注入后，乳头和乳房象限中的IgG1、IgG2、溶菌酶以及在一定程度上的IgM增加，并且与体细胞计数的变化呈正相关。未观察到IgA或乳铁蛋白有显著变化。讨论了牛乳头和乳房中Ig、溶菌酶和乳铁蛋白的来源及意义。Ig可能既来源于血清也来源于局部浆细胞，而白细胞似乎是炎症期间溶菌酶的来源。分泌上皮似乎是乳铁蛋白的来源。支持这一理论的是乳头乳池样本中几乎完全没有乳铁蛋白。
