Hilderson H, Vercruysse J, Berghen P, Dorny P, McKellar Q A
Department of Parasitology, Faculty of Veterinary Medicine, University of Gent.
Zentralbl Veterinarmed B. 1992 May;39(3):187-92. doi: 10.1111/j.1439-0450.1992.tb01157.x.
Gastrin values were evaluated in 130 parasite naive calves, in 61 first season grazing calves during six field trials and in 8 experimentally infected adult immune cows. The gastrin values were linked to pepsinogen levels and daily weight gain. Also the influence of an anthelmintic treatment on pepsinogen and gastrin values was assessed during a clinical outbreak of ostertagiosis in a group of first season grazing calves. Mean gastrin levels in parasite naive calves were 106 pg/ml. Results show that a group mean of 400 pg/ml gastrin in first season grazing calves indicates a reduced daily weight gain but with no obvious clinical signs. During clinical outbreaks mean gastrin levels frequently reached 1,000 pg/ml with a severe weight loss and a mean pepsinogen level of 5,000 mU tyr. The serum gastrin concentration was strongly reduced 4 days post treatment. No gastrin response was noted following an Ostertagia challenge in adult immune cows. The value of gastrin as a diagnostic aid for ostertagiosis is discussed in relation to pepsinogen, the adult worm burden, larval inhibition and the technique involved in assessing gastrin.
对130头未感染寄生虫的犊牛、61头在六个田间试验中的第一季放牧犊牛以及8头经实验感染的成年免疫母牛的胃泌素值进行了评估。胃泌素值与胃蛋白酶原水平和日增重相关。此外，在一组第一季放牧犊牛发生奥斯特他线虫病临床暴发期间，评估了驱虫治疗对胃蛋白酶原和胃泌素值的影响。未感染寄生虫的犊牛的平均胃泌素水平为106 pg/ml。结果表明，第一季放牧犊牛的胃泌素组平均水平为400 pg/ml时，日增重降低，但无明显临床症状。在临床暴发期间，胃泌素平均水平经常达到1000 pg/ml，伴有严重体重减轻，平均胃蛋白酶原水平为5000 mU tyr。治疗后4天血清胃泌素浓度大幅降低。成年免疫母牛经奥斯特他线虫攻击后未观察到胃泌素反应。结合胃蛋白酶原、成虫负荷、幼虫抑制以及评估胃泌素所涉及的技术，讨论了胃泌素作为奥斯特他线虫病诊断辅助手段的价值。
