Foote Simon J, Handman Emanuela
Genetics and Bioinformatics, The Walter and Eliza Hall Institute of Medical Research, Hobart, Tasmania 7000, Australia.
Brief Funct Genomic Proteomic. 2005 Nov;4(3):270-6. doi: 10.1093/bfgp/4.3.270.
Leishmaniasis encompasses a number of disease syndromes, caused by several species of the digenetic protozoan Leishmania, and is transmitted by sandflies. The mouse model of the disease has been used to identify genes involved in disease susceptibility--for example, the Slc11a1 gene, important in resistance to Leishmania donovani--and to map loci important in Leishmania major infection. The genetics of the host response to L. major has been shown to be complex and to involve much more than the T helper cell response.
利什曼病包含多种疾病综合征，由几种双殖类原生动物利什曼原虫引起，并通过白蛉传播。该疾病的小鼠模型已被用于识别与疾病易感性相关的基因——例如，对杜氏利什曼原虫具有抗性的重要基因Slc11a1——以及定位在硕大利什曼原虫感染中起重要作用的基因座。宿主对硕大利什曼原虫反应的遗传学已被证明是复杂的，且涉及的远不止辅助性T细胞反应。
