在非痴呆老年人群中，脑室周围白质高信号的增加与心理加工速度的下降平行。
Increase in periventricular white matter hyperintensities parallels decline in mental processing speed in a non-demented elderly population.
作者信息
van den Heuvel D M J, ten Dam V H, de Craen A J M, Admiraal-Behloul F, Olofsen H, Bollen E L E M, Jolles J, Murray H M, Blauw G J, Westendorp R G J, van Buchem M A
机构信息
Department of Radiology, Leiden University Medical Center, The Netherlands.
出版信息
J Neurol Neurosurg Psychiatry. 2006 Feb;77(2):149-53. doi: 10.1136/jnnp.2005.070193.
OBJECTIVE
To investigate the influence of deep white matter hyperintensities (DWMH) and periventricular white matter hyperintensities (PVWMH) on progression of cognitive decline in non-demented elderly people.
METHODS
All data come from the nested MRI sub-study of the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER). We performed a 3 year follow up study on 554 subjects of the PROSPER study using both repeated magnetic resonance imaging and cognitive testing. Cognitive decline and its dependency on WMH severity was assessed using linear regression models adjusted for sex, age, education, treatment group, and test version when applicable.
RESULTS
We found that the volume of PVWMH at baseline was longitudinally associated with reduced mental processing speed (p = 0.0075). In addition, we found that the progression in PVWMH volume paralleled the decline in mental processing speed (p = 0.024). In contrast, neither presence nor progression of DWMH was associated with change in performance on any of the cognitive tests.
CONCLUSION
PVWMH should not be considered benign but probably underlie impairment in cognitive processing speed.
目的
探讨深部白质高信号（DWMH）和脑室周围白质高信号（PVWMH）对非痴呆老年人认知功能衰退进展的影响。
方法
所有数据均来自“老年高危人群普伐他汀前瞻性研究（PROSPER）”的嵌套式MRI子研究。我们对PROSPER研究中的554名受试者进行了为期3年的随访研究，采用重复磁共振成像和认知测试。认知功能衰退及其对WMH严重程度的依赖性通过线性回归模型进行评估，在适用时对性别、年龄、教育程度、治疗组和测试版本进行了校正。
结果
我们发现，基线时PVWMH的体积与心理加工速度下降呈纵向关联（p = 0.0075）。此外，我们发现PVWMH体积的进展与心理加工速度的下降平行（p = 0.024）。相比之下，DWMH的存在或进展与任何认知测试的表现变化均无关联。
结论
PVWMH不应被视为良性，而可能是认知加工速度受损的基础。
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