Aïda Ayadi-Kaddour, Sana Ben Slama, Essia Saiji, Carole Goutallier-Ben Fadhel, Ahlem Lahmar-Boufaroua, Amel Triki, Sabah Mzabi-Regaya
Service d'Anatomie et de Cytologie Pathologiqes, Hôpital Mongi Slim, La Marsa, Tunis.
Tunis Med. 2005 Nov;83(11):710-3.
Malignant transformation of ovarian mature benign teratomas is an uncommon complication which often occurs in the postmenopausal period. Clinical presentation is similar to that of benign ovarian cysts. The diagnosis of malignant transformation is often made per-operatively by the break of the capsule and the adhesions of the tumor or during histological examination. The diagnosis is based on the association between a mature teratoma and a non metastatic unitissular, carcinoma or sarcoma. All histological forms can be met, but squamous cell carcinoma accounts for 75% of all cases. We report the case of a 70-year-old woman who had a squamous cell carcinoma which developed on a teratoma of the ovary, for whom the disease was fatal. The survival rate for this kind of ovarian tumour is reduced, with 15 to 30% survival after 5 years, irrespective of stages and histological types. Although it is not easy to define the best requested therapy, surgery associated with polychemotherapy or radiotherapy is apparently the only way of improving the poor prognosis for these tumours.
卵巢成熟性良性畸胎瘤恶变是一种罕见的并发症,常发生于绝经后期。临床表现与良性卵巢囊肿相似。恶变的诊断通常在手术中通过包膜破裂和肿瘤粘连或在组织学检查时做出。诊断基于成熟畸胎瘤与非转移性单胚层癌或肉瘤之间的关联。所有组织学类型均可见,但鳞状细胞癌占所有病例的75%。我们报告一例70岁女性,其卵巢畸胎瘤发生了鳞状细胞癌,该疾病导致患者死亡。这类卵巢肿瘤的生存率降低,无论分期和组织学类型如何,5年后生存率为15%至30%。尽管很难确定最佳的所需治疗方法,但手术联合多药化疗或放疗显然是改善这些肿瘤不良预后的唯一方法。