Department of Pathology, Saint Louis University, St. Louis, MO, USA.
Int J Gynecol Pathol. 2012 Sep;31(5):443-6. doi: 10.1097/PGP.0b013e318249289e.
Malignant transformation of a mature ovarian teratoma is a rare occurrence predominantly in the postmenopausal period. All histologic types can be seen; however, squamous cell carcinoma accounts for over 75% of cases. Sarcomatous transformation is much more uncommon, with cases of angiosarcoma, rhabdomyosarcoma, leiomyosarcoma and liposarcoma arising in a mature ovarian teratoma described in literature. We report a case of squamous cell carcinoma and pleomorphic sarcoma arising in a mature cystic teratoma of the ovary in a 58-year-old woman. The tumor shows both epithelial and stromal components. The epithelial component is moderately-differentiated squamous cell carcinoma with foci of keratinization. The stromal component is significant for an abundance of giant cells, enlarged bizarre nuclei, and marked mitotic activity. This is a unique report of malignant transformation of a benign ovarian teratoma showing both epithelial and sarcomatous elements.
成熟卵巢畸胎瘤的恶性转化是一种罕见的现象，主要发生在绝经后。所有组织学类型均可出现，但鳞状细胞癌占 75%以上。肉瘤转化更为罕见，文献中曾描述过成熟卵巢畸胎瘤中发生的血管肉瘤、横纹肌肉瘤、平滑肌肉瘤和脂肪肉瘤。我们报告了一例 58 岁女性成熟囊性卵巢畸胎瘤中发生的鳞状细胞癌和多形性肉瘤。肿瘤显示上皮和间质成分。上皮成分为中分化鳞状细胞癌，伴有角化灶。间质成分丰富的巨细胞、增大的奇异核和明显的有丝分裂活性。这是一例罕见的良性卵巢畸胎瘤发生上皮和肉瘤样成分的恶性转化的报告。
