Greenstein Alexander, Chen Juza, Salonia Andrea, Sofer Mario, Matzkin Haim, Montorsi Francesco
Department of Urology, Tel Aviv Sourasky Medical Centre, Tel Aviv, Israel.
J Sex Med. 2004 Nov;1(3):314-7. doi: 10.1111/j.1743-6109.04045.x.
To assess the effect of sildenafil on nocturnal erectile function (EF) in young healthy volunteers with normal sexual function (SF) according to the International Index of Erectile Function (IIEF) questionnaire.
Thirty-three young (mean age 21 +/- 0.3 years; range 18-25) healthy volunteers not taking any medications who had normal SF and an EF domain >26 on the IIEF questionnaire were evaluated. Erectile function was assessed using the RigiScan (Dacomed Corp., MN, USA) during three nights: night 1 = adaptation to the NPT-Rigiscan apparatus, night 2 = baseline recording of eight parameters, and night 3 = recordings after ingestion of sildenafil 100 mg. Data on the number of erections, erection duration, minimal and maximal base tumescence, minimal and maximal tip tumescence, and base and tip rigidity were analysed using anova with repeated measures.
A statistically significant improvement in all eight parameters was observed as a result of sildenafil administration: number of erections from 3.1 +/- 0.7 to 4.0 +/- 0.7 (P < 0.05), erection time 22 +/- 3.5 to 34.2 +/- 5.9, minimal base tumescence 8.2 +/- 0.8 to 8.7 +/- 0.8, maximal base tumescence 12.1 +/- 0.7 to 14.2 +/- 0.7, base rigidity 75.6 +/- 3.1 to 81.6 +/- 3.6, tip rigidity 70.6 +/- 1.5 to 75.9 +/- 3.1, minimal tip tumescence 5.9 +/- 0.5 to 6.5 +/- 0.6, and maximal tip tumescence 8.6 +/- 0.6 to 11.7 +/- 0.7 (P < 0.0001 for each of the last seven parameters). The mean sleep duration, 7.3 hours (range 6.30-9.20 hours), was similar for both nights of recording.
Sildenafil increases the quality and number of nocturnal erections as tested by the NPT-RigiScan in young healthy volunteers with normal EF.
根据国际勃起功能指数（IIEF）问卷，评估西地那非对性功能正常的年轻健康志愿者夜间勃起功能（EF）的影响。
对33名年轻（平均年龄21±0.3岁；范围18 - 25岁）、未服用任何药物、性功能正常且IIEF问卷中EF领域得分>26的健康志愿者进行评估。在三个晚上使用RigiScan（美国明尼苏达州Dacomed公司）评估勃起功能：第1晚 = 适应夜间阴茎勃起功能监测仪；第2晚 = 记录八个参数的基线数据；第3晚 = 服用100毫克西地那非后的记录数据。使用重复测量方差分析对勃起次数、勃起持续时间、最小和最大阴茎基部肿胀度、最小和最大阴茎头部肿胀度以及阴茎基部和头部硬度的数据进行分析。
服用西地那非后，所有八个参数均有统计学意义的改善：勃起次数从3.1±0.7次增加到4.0±0.7次（P < 0.05），勃起时间从22±3.5分钟增加到34.2±5.9分钟，最小阴茎基部肿胀度从8.2±0.8增加到8.7±0.8，最大阴茎基部肿胀度从12.1±0.7增加到14.2±0.7，阴茎基部硬度从75.6±3.1增加到81.6±3.6，阴茎头部硬度从70.6±1.5增加到75.9±3.1，最小阴茎头部肿胀度从5.9±0.5增加到6.5±0.6，最大阴茎头部肿胀度从8.6±0.6增加到11.7±0.7（最后七个参数每个P < 0.0001）。两个记录晚上的平均睡眠时间为7.3小时（范围6.30 - 9.20小时），相似。
对于夜间勃起功能正常的年轻健康志愿者，通过夜间阴茎勃起功能监测仪测试，西地那非可提高夜间勃起的质量和次数。
