Uphouse Lynda, Hensler Julie G, Sarkar Jhimly, Grossie Bruce
Department of Biology, Texas Woman's University, Denton, TX 76204, USA.
Brain Res. 2006 Feb 9;1072(1):79-90. doi: 10.1016/j.brainres.2005.12.033. Epub 2006 Jan 19.
Adult, regularly cycling female Fischer rats were injected daily with 10 mg/kg fluoxetine for 12-23 days. In the first experiment, body weight and vaginal smears were monitored daily. Fluoxetine treatment reduced body weight within the first 24 h of treatment. Fluoxetine treatment also elongated the estrous cycle, reduced blood levels of progesterone, and eliminated lordosis behavior. In the second experiment, body weight and food intake were examined and a pair-fed group was included to determine if fluoxetine-induced anorexia contributed to the disturbance of the estrous cycle. In pair-fed rats, effects similar to fluoxetine treatment were present. These results lead to the suggestion that fluoxetine's anorectic properties could disrupt the female's normal endocrine cyclicity and that this disruption could be relevant to the reduction in sexual behavior and motivation. However, when the duration of fluoxetine treatment was extended beyond 16 to 17 days, fluoxetine-treated female rats reinitiated vaginal cyclicity and showed evidence of normal sexual receptivity. In contrast, the estrous cycles of their pair-fed counterparts remained disrupted. Thus, restricted food intake appears to contribute to the disruption of the estrous cycle and elimination of sexual receptivity during fluoxetine treatment. However, compensatory changes in the serotonergic system that are associated with chronic fluoxetine administration may contribute to the gradual recovery of estrous cyclicity and sexual receptivity of the fluoxetine-treated animals.
成年、定期骑行的雌性费希尔大鼠每天注射10毫克/千克氟西汀，持续12至23天。在第一个实验中，每天监测体重和阴道涂片。氟西汀治疗在治疗的头24小时内降低了体重。氟西汀治疗还延长了发情周期，降低了孕酮的血液水平，并消除了脊柱前凸行为。在第二个实验中，检查了体重和食物摄入量，并纳入了一对喂食组，以确定氟西汀引起的厌食是否导致发情周期紊乱。在成对喂食的大鼠中，出现了与氟西汀治疗相似的效果。这些结果表明，氟西汀的厌食特性可能会扰乱雌性的正常内分泌周期性，并且这种扰乱可能与性行为和动机的降低有关。然而，当氟西汀治疗的持续时间延长超过16至17天时，接受氟西汀治疗的雌性大鼠重新开始阴道周期性，并表现出正常性接受能力的证据。相比之下，它们成对喂食的对照组的发情周期仍然紊乱。因此，在氟西汀治疗期间，食物摄入量受限似乎导致发情周期紊乱和性接受能力的消除。然而，与慢性氟西汀给药相关的血清素能系统的代偿性变化可能有助于氟西汀治疗动物的发情周期性和性接受能力的逐渐恢复。
