膳食脂肪和热量摄入对大鼠前列腺5α-还原酶-2基因表达及前列腺重量的调节作用
Regulation of prostate 5alpha-reductase-2 gene expression and prostate weight by dietary fat and caloric intake in the rat.
作者信息
Cai Li-Qun, Imperato-McGinley Julianne, Zhu Yuan-Shan
机构信息
Department of Medicine/ Endocrinology, Weill Medical College of Cornell University, New York, New York 10021, USA.
出版信息
Prostate. 2006 May 15;66(7):738-48. doi: 10.1002/pros.20397.
BACKGROUND
High-fat diet is a major risk factor for prostate cancer. 5alpha-reductases are potential targets of dietary fat.
METHODS
Male ACI/Seg rats given either a low-fat or a high-fat diet at weaning or adulthood were sacrificed at 2, 4, and 10 weeks after dietary treatment. Prostate 5alpha-reductase mRNAs, plasma androgens, food consumption, prostate, and body weight were determined.
RESULTS
Prostate 5alpha-reductase-2 mRNA and plasma dihydrotestosterone levels were elevated at 2 weeks, and prostate weight was increased at 10 weeks in neonatal rats fed the high-fat diet. Animals fed the high-fat diet consumed more calories in the first 4 weeks. 5alpha-reductase-1 mRNA, plasma testosterone, and body weight were not different between the two dietary groups. These dietary effects were not observed in adult rats fed the same diets.
CONCLUSION
A high-dietary fat and caloric intake upregulates prostate 5alpha-reductase-2 gene expression, and stimulates prostate growth in neonatal, but not adult rats.
背景
高脂肪饮食是前列腺癌的主要危险因素。5α-还原酶是膳食脂肪的潜在靶点。
方法
断奶或成年后给予低脂或高脂饮食的雄性ACI/Seg大鼠在饮食处理后2、4和10周处死。测定前列腺5α-还原酶mRNA、血浆雄激素、食物摄入量、前列腺和体重。
结果
高脂饮食喂养的新生大鼠在2周时前列腺5α-还原酶-2 mRNA和血浆双氢睾酮水平升高，10周时前列腺重量增加。高脂饮食喂养的动物在最初4周消耗更多热量。两组饮食之间5α-还原酶-1 mRNA、血浆睾酮和体重没有差异。在给予相同饮食的成年大鼠中未观察到这些饮食效应。
结论
高膳食脂肪和热量摄入上调新生大鼠而非成年大鼠的前列腺5α-还原酶-2基因表达，并刺激前列腺生长。
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