食管鳞状细胞癌患者循环T淋巴细胞的术前分类：其预后意义
Preoperative sorting of circulating T lymphocytes in patients with esophageal squamous cell carcinoma: its prognostic significance.
作者信息
Nozoe Tadahiro, Maehara Yoshihiko, Sugimachi Keizo
机构信息
Department of Surgery, Fukuoka Higashi Medical Center, Koga 811-3195, Japan.
出版信息
World J Gastroenterol. 2005 Nov 14;11(42):6689-93. doi: 10.3748/wjg.v11.i42.6689.
Abstract
AIM
To elucidate the immunologic parameters for the outcome of patients with malignant tumors, especially esophageal squamous cell carcinoma (ESCC) associated with high malignant potential.
METHODS
Clinicopathologic features were compared between patients with lower and higher CD4 and CD8 values as well as CD4/CD8 ratio in peripheral blood.
RESULTS
The survival rate of patients with higher CD4 value was significantly better than that in patients with lower CD4 value (P = 0.039). The survival rate of patients with higher CD8 value was significantly worse than that of patients with lower CD8 value (P = 0.026). Similarly, the survival rate of patients with higher CD4/CD8 ratio was significantly better than that of patients with lower CD4/CD8 ratio (P = 0.042). Additionally, multivariate analysis demonstrated that lower CD8 and lower CD4/CD8 ratio were factors independently associated with worse prognosis of patients.
CONCLUSION
All the immunologic parameters can predict the outcome of patients with ESCC.
摘要
目的
阐明恶性肿瘤患者，尤其是具有高恶性潜能的食管鳞状细胞癌（ESCC）患者预后的免疫参数。
方法
比较外周血中CD4和CD8值以及CD4/CD8比值较低和较高的患者的临床病理特征。
结果
CD4值较高的患者的生存率明显优于CD4值较低的患者（P = 0.039）。CD8值较高的患者的生存率明显低于CD8值较低的患者（P = 0.026）。同样，CD4/CD8比值较高的患者的生存率明显优于CD4/CD8比值较低的患者（P = 0.042）。此外，多变量分析表明，较低的CD8和较低的CD4/CD8比值是与患者预后较差独立相关的因素。
结论
所有免疫参数均可预测ESCC患者的预后。
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