Simon H, Drettner B, Jung B
Acta Otolaryngol. 1977 Mar-Apr;83(3-4):378-90.
The mucociliary transport of the human nasal mucosa was studied by using very small resin beads tagged with 51Cr. Several modifications of previous methods were introduced, e.g. kind of nuclide, particle size, pH, mode of application, measuring technique and reduction of local irradiation. Finally arrangements implying exact measurements of transport not only horizontally but also vertically or obliquely were obtained. No mucociliary transport was demonstrated in five of nine subjects with a common cold 10 days before or one week after the investigation. Xylometazolin as a nasal spray diminished the mucociliary transport significantly. In addition, the effects on mucociliary transport caused by homolateral or contralateral experimental nasal obstruction as well as by tobacco smoking were studied in healthy subjects. Finally, patients with various diseases: pollen allergy in free intervals, chronic rhinitis, septal deviation or perforation, and condition after laryngectomy were also investigated.
通过使用标记有51Cr的非常小的树脂珠来研究人鼻黏膜的黏液纤毛运输。引入了对先前方法的若干改进，例如核素种类、颗粒大小、pH值、应用方式、测量技术以及局部辐射的减少。最终获得了不仅能精确测量水平方向，还能测量垂直或倾斜方向运输的装置。在调查前10天或调查后1周患普通感冒的9名受试者中，有5名未显示出黏液纤毛运输。作为鼻喷雾剂的赛洛唑啉显著降低了黏液纤毛运输。此外，还在健康受试者中研究了同侧或对侧实验性鼻阻塞以及吸烟对黏液纤毛运输的影响。最后，还对患有各种疾病的患者进行了研究：花粉过敏缓解期患者、慢性鼻炎患者、鼻中隔偏曲或穿孔患者以及喉切除术后患者。
