内源性谷胱甘肽水平对X射线诱导人淋巴细胞细胞周期延迟的影响。
Influence of endogenous glutathione level on X-ray induced cell cycle delay in human lymphocytes.
作者信息
Ray S, Chatterjee A
机构信息
Genetics Laboratory, Department of Biotechnology and Bioinformatics, North-Eastern Hill University, Shillong, India.
出版信息
Cell Prolif. 2006 Feb;39(1):37-47. doi: 10.1111/j.1365-2184.2006.00365.x.
Abstract
Here, induction of chromosomal aberration after X-irradiation and the pattern of cell cycle kinetics have been investigated in human lymphocytes, after exogenous addition of reduced glutathione or by depleting levels of reduced glutathione endogenously. Involvement of cell cycle regulator proteins such as p53 and p21 has been investigated to elucidate their role in induction of delay in cell cycle progression after irradiation.
摘要
在此，研究了在人淋巴细胞中外源性添加还原型谷胱甘肽或内源性降低还原型谷胱甘肽水平后，X射线照射后染色体畸变的诱导情况以及细胞周期动力学模式。还研究了细胞周期调节蛋白如p53和p21的参与情况，以阐明它们在辐射后诱导细胞周期进程延迟中的作用。
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