哈维氏弧菌GTP酶CgtAV是必需的，且与50S核糖体亚基相关。
The Vibrio harveyi GTPase CgtAV is essential and is associated with the 50S ribosomal subunit.
作者信息
Sikora A E, Zielke R, Datta K, Maddock J R
机构信息
Department of Molecular, Cellular and Developmental Biology, University of Michigan, 830 North University, Ann Arbor, MI 48109-1048, USA.
出版信息
J Bacteriol. 2006 Feb;188(3):1205-10. doi: 10.1128/JB.188.3.1205-1210.2006.
Abstract
It was previously reported that unlike the other obg/cgtA GTPases, the Vibrio harveyi cgtAV is not essential. Here we show that cgtAV was not disrupted in these studies and is, in fact, essential for viability. Depletion of CgtAV did not result in cell elongation. CgtAV is associated with the large ribosomal particle. In light of our results, we predict that the V. harveyi CgtAV protein plays a similar essential role to that seen for Obg/CgtA proteins in other bacteria.
摘要
先前有报道称，与其他obg/cgtA GTP酶不同，哈维弧菌cgtAV并非不可或缺。在此我们表明，在这些研究中cgtAV并未被破坏，而实际上它对于细胞存活至关重要。CgtAV的缺失并未导致细胞伸长。CgtAV与大核糖体颗粒相关联。根据我们的研究结果，我们预测哈维弧菌CgtAV蛋白发挥的重要作用与其他细菌中Obg/CgtA蛋白所起的作用类似。
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