Dicpinigaitis Peter V
Chest. 2006 Jan;129(1 Suppl):284S-286S. doi: 10.1378/chest.129.1_suppl.284S.
When the etiology of a patient's chronic cough is established, specific antitussive therapy that is aimed at a particular cause of cough is highly effective. Nevertheless, in certain situations, therapy with cough suppressants, which previously were classified as nonspecific antitussive therapy, and which aim at suppressing the cough reflex regardless of the cause of cough, will be necessary.
The data for this review were obtained with the aid of a National Library of Medicine (PubMed) search, which was performed in June 2004, of literature published in the English language from 1966 to 2004, using the search terms "cough," "antitussive," "pharmacotherapy," "future therapies, " and "potential therapies."
RESULTS/CONCLUSIONS: Currently available cough-suppressant therapy is severely limited by a dearth of effective agents and/or their unacceptable side effects. Several classes of pharmacologic agents are currently under investigation in an attempt to develop clinically useful cough suppressants.
当确定患者慢性咳嗽的病因后，针对特定咳嗽病因的特异性镇咳治疗非常有效。然而，在某些情况下，使用止咳药进行治疗是必要的，止咳药以前被归类为非特异性镇咳治疗，其目的是抑制咳嗽反射，而不考虑咳嗽的原因。
本综述的数据借助美国国立医学图书馆（PubMed）检索获得，检索于2004年6月进行，检索1966年至2004年以英文发表的文献，使用的检索词为“咳嗽”、“镇咳”、“药物治疗”、“未来治疗”和“潜在治疗”。
结果/结论：目前可用的止咳治疗因有效药物匮乏和/或其不可接受的副作用而受到严重限制。目前正在研究几类药物，试图开发出临床上有用的止咳药。
