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自然产生的针对恶性疟原虫糖基磷脂酰肌醇（GPI）的抗体需要完整的GPI结构才能结合，并且主要针对保守的聚糖部分。

Naturally elicited antibodies to glycosylphosphatidylinositols (GPIs) of Plasmodium falciparum require intact GPI structures for binding and are directed primarily against the conserved glycan moiety.

作者信息

Naik Ramachandra S, Krishnegowda Gowdahalli, Ockenhouse Christian F, Gowda D Channe

机构信息

Department of Biochemistry and Molecular Biology, Pennsylvania State University College of Medicine, 500 University Dr., Hershey, PA 17033, USA.

出版信息

Infect Immun. 2006 Feb;74(2):1412-5. doi: 10.1128/IAI.74.2.1412-1415.2006.

DOI:10.1128/IAI.74.2.1412-1415.2006
PMID:16428795
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1360366/
Abstract

Immunization with a synthetic glycan corresponding to Plasmodium falciparum glycosylphosphatidylinositols (GPIs) has been proposed as a vaccination strategy against malaria. We investigated the structural requirements for binding of naturally elicited anti-GPI antibodies to parasite GPIs. The data show that anti-GPI antibody binding requires intact GPI structures and that the antibodies are directed predominantly against GPIs with a conserved glycan structure with three mannoses and marginally against the terminal fourth mannose. The results provide valuable insight for exploiting GPIs for the development of malaria vaccines.

摘要

用与恶性疟原虫糖基磷脂酰肌醇（GPI）相对应的合成聚糖进行免疫已被提议作为一种抗疟疾疫苗接种策略。我们研究了天然产生的抗GPI抗体与寄生虫GPI结合的结构要求。数据表明，抗GPI抗体结合需要完整的GPI结构，并且这些抗体主要针对具有三个甘露糖的保守聚糖结构的GPI，对末端的第四个甘露糖的结合较弱。这些结果为利用GPI开发疟疾疫苗提供了有价值的见解。

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Naturally elicited antibodies to glycosylphosphatidylinositols (GPIs) of Plasmodium falciparum require intact GPI structures for binding and are directed primarily against the conserved glycan moiety.自然产生的针对恶性疟原虫糖基磷脂酰肌醇（GPI）的抗体需要完整的GPI结构才能结合，并且主要针对保守的聚糖部分。
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2
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本文引用的文献

1
Glycosylphosphatidylinositols in malaria pathogenesis and immunity: potential for therapeutic inhibition and vaccination.糖基磷脂酰肌醇在疟疾发病机制与免疫中的作用：治疗性抑制和疫苗接种的潜力
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Differential antibody responses to Plasmodium falciparum glycosylphosphatidylinositol anchors in patients with cerebral and mild malaria.脑型疟疾和轻度疟疾患者对恶性疟原虫糖基磷脂酰肌醇锚的差异性抗体反应。
Microbes Infect. 2005 Apr;7(4):682-7. doi: 10.1016/j.micinf.2005.01.002. Epub 2005 Mar 21.
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Induction of proinflammatory responses in macrophages by the glycosylphosphatidylinositols of Plasmodium falciparum: cell signaling receptors, glycosylphosphatidylinositol (GPI) structural requirement, and regulation of GPI activity.恶性疟原虫糖基磷脂酰肌醇对巨噬细胞促炎反应的诱导：细胞信号受体、糖基磷脂酰肌醇（GPI）结构要求及GPI活性调节
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Innate immunity to malaria.疟疾的天然免疫
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Age-dependent impairment of IgG responses to glycosylphosphatidylinositol with equal exposure to Plasmodium falciparum among Javanese migrants to Papua, Indonesia.在印度尼西亚巴布亚的爪哇移民中，尽管同等暴露于恶性疟原虫，但对糖基磷脂酰肌醇的IgG反应存在年龄依赖性损伤。
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The war between the malaria parasite and the immune system: immunity, immunoregulation and immunopathology.疟原虫与免疫系统之间的战争：免疫、免疫调节与免疫病理学。
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Immunoglobulin G (IgG) responses to Plasmodium falciparum glycosylphosphatidylinositols are short-lived and predominantly of the IgG3 subclass.针对恶性疟原虫糖基磷脂酰肌醇的免疫球蛋白G（IgG）反应持续时间短，且主要为IgG3亚类。
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8
Antibodies to Plasmodium falciparum glycosylphosphatidylinositols: inverse association with tolerance of parasitemia in Papua New Guinean children and adults.恶性疟原虫糖基磷脂酰肌醇抗体：与巴布亚新几内亚儿童和成人中疟原虫血症耐受性呈负相关。
Infect Immun. 2002 Sep;70(9):5052-7. doi: 10.1128/IAI.70.9.5052-5057.2002.
9
Prevalence and boosting of antibodies to Plasmodium falciparum glycosylphosphatidylinositols and evaluation of their association with protection from mild and severe clinical malaria.恶性疟原虫糖基磷脂酰肌醇抗体的流行率及增强情况以及它们与预防轻度和重度临床疟疾相关性的评估
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Synthetic GPI as a candidate anti-toxic vaccine in a model of malaria.合成糖基磷脂酰肌醇作为疟疾模型中的候选抗毒疫苗。
Nature. 2002 Aug 15;418(6899):785-9. doi: 10.1038/nature00937.