Kaftan Holger, Hosemann Werner
Department of Otorhinolaryngology and Head and Neck Surgery, University of Greifswald, Greifswald, Germany.
ORL J Otorhinolaryngol Relat Spec. 2006;68(2):73-6. doi: 10.1159/000091093. Epub 2006 Jan 20.
The objective of this animal study was to compare topical mitomycin C (MMC) before and after nonlaser myringotomy. Bilateral myringotomies were performed in 12 rats. On the left side, MMC was applied to the intact tympanic membrane for 10 min before myringotomy (preapplication group). On the right side, MMC was applied to the tympanic membrane following myringotomy. Tympanic membranes were observed for a total of 8 weeks. By day 35, all myringotomies with application of MMC after perforation of the tympanic membrane were closed, whereas 42% of the myringotomies with application of MMC prior to perforation remained patent. One tympanic membrane in the preapplication group showed an enlargement of the perforation with partial destruction of the malleus. The present study showed that the application of MMC to the intact tympanic membrane prolongs the patency of nonlaser myringotomies in rats. Specific side effects of the MMC application must be kept in mind.
这项动物研究的目的是比较非激光鼓膜切开术前和术后局部应用丝裂霉素C（MMC）的效果。对12只大鼠进行双侧鼓膜切开术。在左侧，在鼓膜切开术前将MMC应用于完整的鼓膜10分钟（术前应用组）。在右侧，在鼓膜切开术后将MMC应用于鼓膜。对鼓膜进行了总共8周的观察。到第35天时，鼓膜穿孔后应用MMC的所有鼓膜切开术均已闭合，而鼓膜穿孔前应用MMC的鼓膜切开术中有42%仍保持开放。术前应用组中有一张鼓膜穿孔扩大，锤骨部分破坏。本研究表明，将MMC应用于完整的鼓膜可延长大鼠非激光鼓膜切开术的开放时间。必须牢记MMC应用的特定副作用。
