[用于治疗鼓膜穿孔的纤维蛋白凝胶：一种实验动物模型]
[Fibrin gel for treatment of tympanic membrane perforations: an experimental animal model].
作者信息
Kaftan H, Eyrich D, Schindler E, Göpferich A, Hosemann W
机构信息
Klinik und Poliklinik für Hals-Nasen- und Ohrenkrankheiten, Kopf- und Halschirurgie, Ernst-Moritz-Arndt-Universität, Walther-Rathenau-Str. 43-45, 17475, Greifswald.
出版信息
HNO. 2006 Dec;54(12):943-6. doi: 10.1007/s00106-006-1395-6.
BACKGROUND
The goal of this study was to evaluate the effects of a fibrin gel on the healing of tympanic membrane perforation in rats.
METHODS
Prolonged tympanic membrane perforations in 12 rats were created by application of mitomycin C to the intact tympanic membranes followed by bilateral myringotomy. Repeated applications of a fibrin gel to the perforation site of one tympanic membrane were performed in each animal. Tympanic membranes were observed for a total of 8 weeks.
RESULTS
One perforation in each group was already patent at the end of the observation period. The mean healing period of the remaining tympanic membranes was found to be 16.7 days in the fibrin gel group and 19.6 days in the control group.
CONCLUSION
A fibrin sheet does not seem to promote the wound healing process of tympanic membranes. However, the sheet might serve as a drug-delivery system for growth factors in the treatment of tympanic membrane perforations, because of its biocompatibility.
背景
本研究的目的是评估纤维蛋白凝胶对大鼠鼓膜穿孔愈合的影响。
方法
通过向完整鼓膜应用丝裂霉素C，随后进行双侧鼓膜切开术，在12只大鼠中造成长期鼓膜穿孔。对每只动物的一侧鼓膜穿孔部位重复应用纤维蛋白凝胶。共观察鼓膜8周。
结果
在观察期结束时，每组各有1处穿孔已愈合。发现纤维蛋白凝胶组其余鼓膜的平均愈合时间为16.7天，对照组为19.6天。
结论
纤维蛋白片似乎并不能促进鼓膜的伤口愈合过程。然而，由于其生物相容性，该片可能作为生长因子的药物递送系统用于治疗鼓膜穿孔。
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