Galletly D C, Corfiatis T, Westenberg A M, Robinson B J
Section of Anaesthesia, Wellington School of Medicine, New Zealand.
Br J Anaesth. 1992 Apr;68(4):360-4. doi: 10.1093/bja/68.4.360.
This study examined the variation in cardiac inter-beat interval during induction of anaesthesia with propofol and subsequent inhalation anaesthesia with nitrous oxide and isoflurane. In comparison with preoperative control values, heart rate variability was reduced by anaesthesia and there was a complex, but consistent, pattern of R-R interval change during induction. Immediately after propofol 2 mg kg-1, high frequency heart rate oscillations were replaced by low frequency oscillations (0.05 Hz). Subsequently, with decreasing propofol and deepening nitrous oxide-isoflurane anaesthesia, high frequency components returned towards, although not reaching, control values; low and, to a greater extent, mid range (0.1-Hz) frequency components remained reduced. We postulate that these alterations are consistent with an immediate but transient post-induction ventilatory depression, subsequent decrease in efferent sympathetic activity and reduction in baroreflex responsiveness. R-R interval analysis is suggested to be a useful tool in the evaluation of autonomic function during anaesthesia.
本研究考察了丙泊酚诱导麻醉以及随后使用氧化亚氮和异氟烷进行吸入麻醉期间心脏搏动间期的变化。与术前对照值相比，麻醉使心率变异性降低，诱导期间R-R间期变化模式复杂但具有一致性。静脉注射2mg/kg丙泊酚后，高频心率振荡立即被低频振荡（0.05Hz）取代。随后，随着丙泊酚浓度降低以及氧化亚氮-异氟烷麻醉加深，高频成分虽未恢复至对照值，但向对照值方向回升；低频以及在更大程度上的中频（0.1Hz）成分仍降低。我们推测，这些改变与诱导后即刻但短暂的通气抑制、随后传出交感神经活动降低以及压力反射反应性降低一致。R-R间期分析被认为是评估麻醉期间自主神经功能的有用工具。
