• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

新开发的肟类药物与现有肟类药物在体外和体内重新激活被神经毒剂抑制的乙酰胆碱酯酶的效力比较。

Comparison of the potency of newly developed and currently available oximes to reactivate nerve agent-inhibited acetylcholinesterase in vitro and in vivo.

作者信息

Kuca Kamil, Bartosova Lucie, Kassa Jiri, Cabal Jiri, Bajgar Jiri, Kunesova Gabriela, Jun Daniel

机构信息

Department of Toxicology, Faculty of Military Health Sciences, Hradec Kralove, Czech Republic.

出版信息

Chem Biol Interact. 2005 Dec 15;157-158:367-8. doi: 10.1016/j.cbi.2005.10.054.

DOI:10.1016/j.cbi.2005.10.054
PMID:16429489
Abstract

Reactivation potency of three newly developed oximes K027, K033 and K048 was tested using standard in vitro and in vivo reactivation tests. K027 and K048 seem to be efficacious reactivators of tabun-inhibited acetylcholinesterase. K033 is sufficient reactivator of cyclosarin-inhibited AChE. However, its potency is poor compared with current "gold standard" oxime HI-6.

摘要

使用标准的体外和体内再激活试验，对三种新开发的肟类化合物K027、K033和K048的再激活效力进行了测试。K027和K048似乎是塔崩抑制的乙酰胆碱酯酶的有效再激活剂。K033是环沙林抑制的乙酰胆碱酯酶的充分再激活剂。然而，与目前的“金标准”肟类化合物HI-6相比，其效力较差。

相似文献

1
Comparison of the potency of newly developed and currently available oximes to reactivate nerve agent-inhibited acetylcholinesterase in vitro and in vivo.新开发的肟类药物与现有肟类药物在体外和体内重新激活被神经毒剂抑制的乙酰胆碱酯酶的效力比较。
Chem Biol Interact. 2005 Dec 15;157-158:367-8. doi: 10.1016/j.cbi.2005.10.054.
2
A comparison of the potency of newly developed oximes (K005, K027, K033, K048) and currently used oximes (pralidoxime, obidoxime, HI-6) to reactivate sarin-inhibited rat brain acetylcholinesterase by in vitro methods.通过体外方法比较新开发的肟类化合物（K005、K027、K033、K048）与目前使用的肟类化合物（解磷定、双复磷、HI-6）对沙林抑制的大鼠脑乙酰胆碱酯酶的重活化能力。
J Toxicol Environ Health A. 2005 Apr 23;68(8):677-86. doi: 10.1080/15287390590921784.
3
In vitro reactivation of tabun-inhibited acetylcholinesterase using new oximes--K027, K005, K033 and K048.使用新型肟类化合物（K027、K005、K033和K048）对塔崩抑制的乙酰胆碱酯酶进行体外复活研究。
Cent Eur J Public Health. 2004 Mar;12 Suppl:S59-61.
4
New quaternary pyridine aldoximes as casual antidotes against nerve agents intoxications.新型季铵吡啶肟作为神经性毒剂中毒的通用解毒剂。
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2005 Jun;149(1):75-82. doi: 10.5507/bp.2005.008.
5
In vitro and in vivo evaluation of pyridinium oximes: mode of interaction with acetylcholinesterase, effect on tabun- and soman-poisoned mice and their cytotoxicity.吡啶肟类化合物的体外和体内评价：与乙酰胆碱酯酶的相互作用模式、对塔崩和梭曼中毒小鼠的影响及其细胞毒性。
Toxicology. 2006 Feb 15;219(1-3):85-96. doi: 10.1016/j.tox.2005.11.003. Epub 2005 Dec 5.
6
A comparison of the ability of a new bispyridinium oxime--1-(4-hydroxyiminomethylpyridinium)-4-(4-carbamoylpyridinium)butane dibromide and currently used oximes to reactivate nerve agent-inhibited rat brain acetylcholinesterase by in vitro methods.通过体外方法比较一种新型双吡啶肟——1-(4-羟基亚氨基甲基吡啶鎓)-4-(4-氨甲酰基吡啶鎓)丁烷二溴化物与目前使用的肟类药物对神经毒剂抑制的大鼠脑乙酰胆碱酯酶的重活化能力。
J Enzyme Inhib Med Chem. 2003 Dec;18(6):529-35. doi: 10.1080/14756360310001605552.
7
Potency of new structurally different oximes to reactivate cyclosarin-inhibited human brain acetylcholinesterases.新型结构不同的肟类化合物对环沙林抑制的人脑乙酰胆碱酯酶的重活化能力。
J Enzyme Inhib Med Chem. 2006 Dec;21(6):663-6. doi: 10.1080/14756360600850916.
8
In vitro reactivation of acetylcholinesterase inhibited by cyclosarin using bisquaternary pyridinium aldoximes K005, K033, K027 AND K048.使用双季铵吡啶肟K005、K033、K027和K048对被环沙林抑制的乙酰胆碱酯酶进行体外重新激活。
Acta Medica (Hradec Kralove). 2004;47(2):107-9.
9
A comparison of the efficacy of a bispyridinium oxime--1,4-bis-(2-hydroxyiminomethylpyridinium) butane dibromide and currently used oximes to reactivate sarin, tabun or cyclosarin-inhibited acetylcholinesterase by in vitro methods.通过体外方法比较双吡啶肟——1,4 - 双（2 - 羟基亚氨基甲基吡啶）丁烷二溴化物与目前使用的肟类药物对沙林、塔崩或环沙林抑制的乙酰胆碱酯酶的复活效果。
Pharmazie. 2004 Oct;59(10):795-8.
10
[A comparison of the efficacy of the reactivators of acetylcholinesterase inhibited with tabun].[对被塔崩抑制的乙酰胆碱酯酶复活剂疗效的比较]
Ceska Slov Farm. 2005 Jul;54(4):192-5.

引用本文的文献

1
The Experimental Oxime K027-A Promising Protector From Organophosphate Pesticide Poisoning. A Review Comparing K027, K048, Pralidoxime, and Obidoxime.实验性肟类化合物K027——有机磷农药中毒的一种有前景的保护剂。K027、K048、解磷定和双复磷的比较综述
Front Neurosci. 2019 May 22;13:427. doi: 10.3389/fnins.2019.00427. eCollection 2019.