Stereoselective effect of phenprocoumon enantiomers on the binding of benzodiazepines to human serum albumin.
作者信息
Fitos I, Simonyi M
机构信息
Central Research Institute for Chemistry, Hungarian Academy of Sciences, Budapest.
出版信息
Chirality. 1992;4(1):21-3. doi: 10.1002/chir.530040106.
PMID:1642965
Abstract
The effect of phenprocoumon enantiomers on the stereoselective binding of 3-substituted 1,4-benzodiazepines to human serum albumin (HSA) was studied by chromatography on HSA-Sepharose column. (S)-Phenprocoumon exerts stereoselective allosteric interaction on the binding of benzodiazepines. The structural requirements of enhanced stereoselectivities are similar to those found previously with (S)-warfarin.
摘要
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