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Stereoselective allosteric binding interaction on human serum albumin between ibuprofen and lorazepam acetate.

作者信息

Fitos I, Visy J, Simonyi M, Hermansson J

机构信息

Institute of Chemistry, Hungarian Academy of Sciences, Budapest, Hungary.

出版信息

Chirality. 1999;11(2):115-20. doi: 10.1002/(SICI)1520-636X(1999)11:2<115::AID-CHIR6>3.0.CO;2-R.

DOI:10.1002/(SICI)1520-636X(1999)11:2<115::AID-CHIR6>3.0.CO;2-R
PMID:9951402
Abstract

The effect of ibuprofen enantiomers on the stereoselective binding of 3-acyloxy-1,4-benzodiazepines to human serum albumin (HSA) was studied using both native and Sepharose-immobilized protein. (S)-Lorazepam acetate exhibited considerably enhanced binding, especially in the presence of (+)-(S)-ibuprofen. The phenomenon is an indication of cooperative allosteric interaction between different binding sites during multiple cobinding of two ligands.

摘要

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