Naeem Ismat, Anwar Raheela, Khan Tahira Moeen
Department of Pharmacy, Lahore College for Women University, Jail Road, Lahore.
Pak J Pharm Sci. 2005 Apr;18(2):3-5.
The crude ethanolic extract of Saracococca saligna was found to be cytotoxic and antibacterial but produced no platelet aggregation induced by ADP. Antibacterial activity of two known alkaloid, pachyaximine-A and saracodine was determined. Pachyaximine-A possessed significant antibacterial activity against Escherichia coli, Staphylococcus aureus, Corynebacterium diphtheriae and Corynebacterium pyrogenes. Saracodme showed moderate activity against Staphylococcus pyrogenes, Escherichia coli, Staphylococcus aureus, Corynebacterium diphtheriae, Shigella boydii and Klebsiella pneumoniae.
柳叶荚蒾的粗乙醇提取物具有细胞毒性和抗菌性，但不会产生由二磷酸腺苷诱导的血小板聚集。测定了两种已知生物碱——粗榧新碱-A和荚蒾碱的抗菌活性。粗榧新碱-A对大肠杆菌、金黄色葡萄球菌、白喉棒状杆菌和产热棒状杆菌具有显著的抗菌活性。荚蒾碱对产热葡萄球菌、大肠杆菌、金黄色葡萄球菌、白喉棒状杆菌、鲍氏志贺菌和肺炎克雷伯菌表现出中等活性。
