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[人类免疫缺陷病毒感染中p24抗原和抗体水平的定量分析]

[Quantification of the levels of p24 antigen and antibodies in human immunodeficiency virus infection].

作者信息

García F, Quirós E, Bernal M C, Alados J C, González M I, Maroto M C

机构信息

Departamento de Microbiología, Facultad de Medicina, Granada.

出版信息

Enferm Infecc Microbiol Clin. 1992 Feb;10(2):75-8.

PMID:1643142
Abstract

BACKGROUND

Quantification and clinical evaluation of p24 antigen and anti-HIV antibody levels.

METHODS

Follow up of 13 HIV infected patients (53 sera) by determination of p24 antigen, total anti-HIV antibodies, anti-p24 and anti-env antibodies by ELISA and their semiquantitation. IgG and IgM class antibody determination by immunoblot techniques.

RESULTS

The highest levels of p24 have been found in WR 1 and WR 6 stages. Commonly accepted serologic pattern has not been found in 100% of our cases. Western-blot is more sensitive for the detection of anti-p24 antibodies.

CONCLUSIONS

p24 antigen appearance and a decrease in anti-p24 antibody level is related to a worse clinical prognosis. p24 antigen quantification is a usefull test for monitoring AZT therapy in patients suffering from AIDS.

摘要

背景

p24抗原和抗HIV抗体水平的定量及临床评估。

方法

通过酶联免疫吸附测定法（ELISA）测定13例HIV感染患者（53份血清）的p24抗原、总抗HIV抗体、抗p24和抗env抗体，并进行半定量分析，对其进行随访。采用免疫印迹技术测定IgG和IgM类抗体。

结果

在WR 1期和WR 6期发现p24水平最高。在我们100%的病例中未发现公认的血清学模式。免疫印迹法在检测抗p24抗体方面更敏感。

结论

p24抗原的出现及抗p24抗体水平的降低与较差的临床预后相关。p24抗原定量对于监测艾滋病患者的齐多夫定（AZT）治疗是一项有用的检测。

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