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用于评估视网膜杂散光的补偿比较方法。

Compensation comparison method for assessment of retinal straylight.

作者信息

Franssen Luuk, Coppens Joris E, van den Berg Thomas J T P

机构信息

Netherlands Ophthalmic Research Institute, Royal Netherlands Academy of Arts and Sciences, Amsterdam, The Netherlands.

出版信息

Invest Ophthalmol Vis Sci. 2006 Feb;47(2):768-76. doi: 10.1167/iovs.05-0690.

Abstract

PURPOSE

Presently, no instrument or method exists that is generally accepted for routine clinical assessment of (functional) retinal straylight. Yet retinal straylight is the cause of major patient complaints, such as hindrance from glare and loss of contrast. It results from disturbances in the optical media that increase light-scattering over angles of 1 degrees to 90 degrees . Its assessment would help to decide whether to perform surgery for (early) cataract and would help in the evaluation of corneal or vitreal turbidity.

METHODS

The psychophysical technique of the "direct compensation" method was adapted to make it suitable for routine clinical assessment. In the new approach, called "compensation comparison, " the central test field is subdivided into two half fields: one with and one without counterphase compensation light. The subject's task is a forced-choice comparison between the two half fields, to decide which half flickers more strongly. A theoretical form for the respective psychometric function was defined and experimentally verified in a laboratory experiment involving seven subjects, with and without artificially increased light scattering. The method was applied in a separate multicenter study. Its reliability was additionally tested with a commercial implement (C-Quant; Oculus Optikgeräte, Wetzlar-Dutenhofen, Germany).

RESULTS

A repeated-measures SD of 0.07 log units was achieved, to be compared with differences in the young normal population of 0.4 log units and an increase with healthy aging by 0.5 log units at 80 years and by 1.0 or more log units with (early) cataract or corneal disturbances. Reliability was further found to be high when using the commercial version of the

CONCLUSIONS

The compensation comparison method for measuring retinal straylight is suited for clinical use to diagnose patients with complaints caused by large angle light scattering in the eye such as early cataract.

摘要

目的

目前,尚无被普遍接受的用于(功能性)视网膜杂散光常规临床评估的仪器或方法。然而,视网膜杂散光却是导致患者出现诸如眩光干扰和对比度下降等主要不适的原因。它是由眼内光学介质的紊乱引起的,这种紊乱会使光在1度至90度的角度范围内发生散射增加。对其进行评估有助于决定是否对(早期)白内障患者实施手术,也有助于评估角膜或玻璃体混浊情况。

方法

对“直接补偿”法的心理物理学技术进行了改进,使其适用于常规临床评估。在这种名为“补偿比较”的新方法中,中央测试区域被细分为两个半区:一个有反相补偿光,另一个没有。受试者的任务是在这两个半区之间进行强制选择比较,以确定哪个半区闪烁得更强烈。定义了相应心理测量函数的理论形式,并在一项涉及7名受试者的实验室实验中进行了实验验证,实验中人为增加或未增加光散射情况。该方法还应用于一项单独的多中心研究。此外,还使用一种商用仪器(C-Quant;德国韦茨拉尔-杜滕霍芬的奥culus Optikgeräte公司)对其可靠性进行了测试。

结果

重复测量标准差达到0.07对数单位,与之相比,年轻正常人群的差异为0.4对数单位,80岁健康老年人增加0.5对数单位,而(早期)白内障或角膜疾病患者增加1.0或更多对数单位。使用该方法的商用版本时,发现可靠性进一步提高。

结论

用于测量视网膜杂散光的补偿比较法适用于临床,可用于诊断因眼内大角度光散射引起不适的患者,如早期白内障患者。

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