Nisselle A E, Collins V R, Gason A A, Flouris A, Delatycki M B, Allen K J, Aitken M A, Metcalfe S A
Genetics Education and Health Research, Murdoch Childrens Research Institute, Parkville, Australia.
Clin Genet. 2006 Feb;69(2):163-70. doi: 10.1111/j.1399-0004.2005.00566.x.
Education is an essential component of a genetic screening program. Knowledge outcomes were measured after large-scale workplace education and screening for genetic susceptibility to hereditary hemochromatosis. The aim was to assess knowledge of concepts presented, impact of mode of delivery, and knowledge retention. Education in a group setting was delivered via oral or video presentation and knowledge assessed using self-administered questionnaires at baseline, 1 month, and 12 months. Over 60% of 11 679 participants correctly answered all questions at baseline, scoring higher with clinical concepts (disease etiology and treatment) than genetic concepts (penetrance and genetic heterogeneity). Revising the education program significantly increased correct responses for etiology (p < 0.002), whilst modifying the knowledge assessment tool significantly increased correct responses for etiology (p < 0.001) and gene penetrance (p < 0.001). For three of the four concepts assessed, use of video was as effective as oral presentation for knowledge outcomes. A significantly higher proportion of those at increased risk of disease (n = 44) responded correctly at 12 months than did controls (n = 82; p = 0.011 for etiology, p = 0.002 for treatment and p = 0.003 for penetrance). Hence, genetic screening can be successfully offered in a group workplace setting, with participants remembering clinical concepts better than genetic concepts up to 1 year later.
教育是基因筛查项目的重要组成部分。在对遗传性血色素沉着症的基因易感性进行大规模职场教育和筛查后，对知识成果进行了测量。目的是评估对所呈现概念的了解、授课方式的影响以及知识保留情况。小组授课通过口头或视频演示进行，并在基线、1个月和12个月时使用自填问卷评估知识。11679名参与者中超过60%在基线时正确回答了所有问题，在临床概念（疾病病因和治疗）方面的得分高于基因概念（外显率和基因异质性）。修订教育项目显著提高了病因方面的正确回答率（p < 0.002），而修改知识评估工具显著提高了病因（p < 0.001）和基因外显率（p < 0.001）方面的正确回答率。对于所评估的四个概念中的三个，视频授课在知识成果方面与口头演示同样有效。疾病风险增加的人群（n = 44）中，在12个月时正确回答的比例显著高于对照组（n = 82；病因方面p = 0.011，治疗方面p = 0.002，外显率方面p = 0.003）。因此，基因筛查可以在职场小组环境中成功开展，参与者对临床概念的记忆在长达1年后仍优于基因概念。
