Staubach P, Eckhardt-Henn A, Dechene M, Vonend A, Metz M, Magerl M, Breuer P, Maurer M
Department of Dermatology, University of Mainz, Germany.
Br J Dermatol. 2006 Feb;154(2):294-8. doi: 10.1111/j.1365-2133.2005.06976.x.
Chronic urticaria (CU), one of the most common skin disorders, is characterized by spontaneous recurrent bouts of weals and pruritus and associated with severely impaired quality of life (QoL).
To determine what aspects of life quality are affected and to characterize the factors that impact on QoL in CU patients.
This interdisciplinary interview/questionnaire-based study included 100 patients admitted to a University Hospital Dermatology Department for the identification of underlying causes of CU; 96 healthy subjects matched for age and sex were used as controls. QoL was assessed using Skindex-29, a validated instrument to measure the effects of skin disease on overall QoL (composite score) and three defined QoL aspects (emotions, symptoms, functioning).
CU patients exhibited markedly reduced overall QoL compared with healthy control subjects. CU had distinct effects on the three QoL aspects assessed (functioning = emotions > symptoms). The age or sex of patients, the absence or presence of angio-oedemas, and the duration or cause of CU did not significantly influence QoL impairment. Interestingly, psychiatric comorbidity (depression, anxiety, somatoform disorders) was associated with a more pronounced reduction of QoL compared with CU patients without a psychiatric diagnosis and the severity of psychiatric disease was found to correlate with QoL impairment.
Our data confirm that overall QoL is markedly reduced in CU patients. Social functioning and emotions were found to be the areas of QoL most affected in CU patients. Psychiatric comorbidity significantly increased QoL impairment, whereas QoL in CU patients was not significantly affected by age or sex, the absence or presence of angio-oedema, or the course or cause of CU.
慢性荨麻疹（CU）是最常见的皮肤疾病之一，其特征为风团和瘙痒的自发性反复发作，并伴有严重的生活质量（QoL）受损。
确定生活质量的哪些方面受到影响，并描述影响CU患者生活质量的因素。
这项基于跨学科访谈/问卷调查的研究纳入了100名因CU潜在病因诊断而入住大学医院皮肤科的患者；96名年龄和性别匹配的健康受试者作为对照。使用Skindex-29评估生活质量，Skindex-29是一种经过验证的工具，用于测量皮肤疾病对整体生活质量（综合评分）以及三个定义的生活质量方面（情绪、症状、功能）的影响。
与健康对照受试者相比，CU患者的整体生活质量显著降低。CU对所评估的三个生活质量方面有明显影响（功能 = 情绪 > 症状）。患者的年龄或性别、血管性水肿的有无、CU的病程或病因均未显著影响生活质量受损情况。有趣的是，与未诊断出精神疾病的CU患者相比，合并精神疾病（抑郁、焦虑、躯体形式障碍）与更明显的生活质量降低相关，并且发现精神疾病的严重程度与生活质量受损相关。
我们的数据证实CU患者的整体生活质量显著降低。社会功能和情绪是CU患者生活质量受影响最大的领域。合并精神疾病显著增加了生活质量受损程度，而CU患者的生活质量未受到年龄或性别、血管性水肿的有无、CU的病程或病因的显著影响。
