Drewes Siegfried E, Mudau K Esther, van Vuuren Sandy F, Viljoen Alvaro M
School of Chemistry, University of KwaZulu-Natal, Private Bag X01, Scottsville 3209, Pietermaritzburg, South Africa.
Phytochemistry. 2006 Apr;67(7):716-22. doi: 10.1016/j.phytochem.2005.12.015. Epub 2006 Jan 24.
The hexane extract of fresh air-dried leaves of Helichrysum tenax (Asteraceae) afforded ent-beyer-15-en-19-ol (1), its 4-epimer ent-beyer-15-en-18-ol (2), 15beta,16beta-epoxide-ent-beyeran-19-ol (3), as well as (4) consisting of two units of (1) linked as a diester of malonic acid, and (5), a compound. Its constituents are (1) and (3) also linked as a diester of malonic acid. The leaves of the plant are densely covered in fine glandular trichomes. These are extremely sticky and exude a mixture of the above diterpenes. Antimicrobial tests showed that (1), in particular, was highly active (3.1 and 3.6 microg/ml) against Bacillus cereus and Staphylococcus epidermidis, respectively.
坚叶蜡菊（菊科）新鲜风干叶片的己烷提取物得到了对映贝壳杉-15-烯-19-醇（1）、其4-差向异构体对映贝壳杉-15-烯-18-醇（2）、15β,16β-环氧-对映贝壳杉烷-19-醇（3），以及由两个（1）单元以丙二酸二酯形式连接而成的化合物（4）和化合物（5）。其成分（1）和（3）也以丙二酸二酯形式连接。该植物的叶片密布着细小的腺毛。这些腺毛极其黏腻，会渗出上述二萜类化合物的混合物。抗菌测试表明，（1）尤其对蜡样芽孢杆菌和表皮葡萄球菌具有高活性（分别为3.1和3.6微克/毫升）。
