Department of Biotechnology, University of Ribeirão Preto (UNAERP), Av. Costábile Romano, 2201, CEP 14096-900, Ribeirão Preto, SP, Brazil.
Molecules. 2012 Jul 25;17(8):8851-8. doi: 10.3390/molecules17088851.
Croton antisyphiliticus is a medicinal plant widely used in the treatment of microbial infections, especially those affecting the genital tract. Crude extract, fractions and pure compound isolated from roots of this species were investigated to validate their antimicrobial activity against Escherichia coli and Staphylococcus aureus. The compound ent-kaur-16-en-18-oic acid was isolated as a major component (0.7% of crude extract), and its MIC value determined against S. aureus (ATCC 6538) was 250 μg/mL. This is the first phytochemical work on the species monitored with antimicrobial assay.
巴豆是一种药用植物，广泛用于治疗微生物感染，特别是影响生殖道的感染。对该种植物的根的粗提物、馏分和分离得到的纯化合物进行了研究，以验证它们对大肠杆菌和金黄色葡萄球菌的抗菌活性。分离出的化合物 ent-kaur-16-en-18-oic acid 是主要成分（粗提取物的 0.7%），其对金黄色葡萄球菌（ATCC 6538）的 MIC 值为 250μg/mL。这是对该种植物进行抗菌活性监测的首次植物化学研究。
