Grytten N, Glad S B, Aarseth J H, Nyland H, Midgard R, Myhr K-M
National Multiple Sclerosis Competence Centre, Haukeland University Hospital, Bergen, Norway.
Neurology. 2006 Jan 24;66(2):182-6. doi: 10.1212/01.wnl.0000195549.95448.b9.
To assess longitudinal follow-up of the incidence of multiple sclerosis (MS) through five decades and estimate the prevalence rate in Hordaland County, Norway, on January 1, 2003.
All patients with MS diagnosed from 1953 to 2003 were identified in the patient records of the Department of Neurology, Haukeland University Hospital, Bergen, Norway. The diagnostic criteria of Poser et al. were applied and only patients with definite and probable MS were included. The study comprises 912 patients, and 666 patients with MS were living in Hordaland on January 1, 2003. The annual incidence rates for the years 1953 to 2003 were calculated.
The total crude prevalence rate on January 1, 2003, was 150.8 per 100,000 population: 191.3 per 100,000 among women and 109.8 per 100,000 among men. The annual incidence of MS increased from 1.8 per 100,000 in 1953 to 1957 to 6.0 per 100,000 in 1993 to 1997.
Hordaland County, Norway, has changed from a low-risk to a high-risk area for multiple sclerosis (MS) during the last 50 years. During the last 25 years, the incidence of MS has been stable rather than increasing. Systematic longitudinal follow-up studies are essential to calculate reliable prevalence and incidence rates in MS. The results suggest that both methodologic and environmental factors are essential in determining the distribution of MS.
评估五十年来多发性硬化症（MS）发病率的纵向随访情况，并估算2003年1月1日挪威霍达兰郡的患病率。
在挪威卑尔根市豪克兰大学医院神经科的患者记录中，识别出所有在1953年至2003年期间被诊断为MS的患者。采用波泽等人的诊断标准，仅纳入确诊和可能患有MS的患者。该研究包括912名患者，2003年1月1日有666名MS患者居住在霍达兰郡。计算了1953年至2003年的年发病率。
2003年1月1日的总粗患病率为每10万人150.8例：女性为每10万人191.3例，男性为每10万人109.8例。MS的年发病率从1953年至1957年的每10万人1.8例增至1993年至1997年的每10万人6.0例。
在过去50年中，挪威霍达兰郡已从多发性硬化症（MS）的低风险地区转变为高风险地区。在过去25年中，MS的发病率一直稳定而非上升。系统性的纵向随访研究对于计算MS可靠的患病率和发病率至关重要。结果表明，方法学和环境因素在决定MS的分布方面都至关重要。
