Kim Myung Shin, Jung Hye-Kyung, Jung Hae Sun, Choi Ju Young, Na Yoon Ju, Pyun Gun Woo, Ryu Jung Hwa, Moon Il Hwan, Jo Min Sun
Department of Internal Medicine, Ewha Womans University College of Medicine, Seoul, Korea.
Korean J Gastroenterol. 2006 Jan;47(1):59-64.
We describe a 58-year-old woman who was incidentally found to have gastric and colonic polyposis, hypoalbuminemia, cutaneous hyperpigmentation and onychodystrophy (Cronkhite-Canada syndrome). Histology of polyps from the stomach showed features of juvenile or retention type (hamartomatous) polyps with Helicobacter pylori (H. pylori) infection. The large pedunculated colonic polyps showed hamartomatous polyps with adenomatous component and polypectomy was performed. After the treatment with H. pylori eradication and omeprazole, the gastric polyposis, hypoalbuminemia and anemia regressed, and endoscopic polypectomy of gastric polyps were performed. After the continuous use of omeprazole for 14 months, the patient showed complete resolution of clinical features of Cronkhite-Canada syndrome. The experience of this case suggests that eradication of H. pylori and proton pump inhibitor treatment might be considered in patients with gastric polyposis combined with Cronkhite-Canada syndrome.
我们描述了一名58岁女性，她被偶然发现患有胃和结肠息肉病、低白蛋白血症、皮肤色素沉着和甲营养不良（克朗凯特-加拿大综合征）。胃息肉的组织学检查显示为青少年型或潴留型（错构瘤性）息肉，并伴有幽门螺杆菌（H. pylori）感染。大的带蒂结肠息肉显示为具有腺瘤成分的错构瘤性息肉，并进行了息肉切除术。在根除幽门螺杆菌并使用奥美拉唑治疗后，胃息肉病、低白蛋白血症和贫血有所缓解，并对胃息肉进行了内镜下息肉切除术。在持续使用奥美拉唑14个月后，患者克朗凯特-加拿大综合征的临床特征完全消失。该病例的经验表明，对于合并克朗凯特-加拿大综合征的胃息肉病患者，可考虑根除幽门螺杆菌并使用质子泵抑制剂进行治疗。
