Cooper B T, Walsh C H, Holmes G K, Wright A D, Cooke W T, Bloom S R
Nutritional and Intestinal Unit and Diabetic Clinic, General Hospital, Birmingham, England.
Scand J Gastroenterol. 1981 Apr;16(3):411-5. doi: 10.3109/00365528109181989.
The responses of plasma gastric inhibitory polypeptide (GIP) and insulin to oral glucose were studied in five patients with untreated coeliac disease. These patients were restudied after one year on a gluten-free diet. In the untreated patients, the blood glucose, serum insulin, and GIP levels were significantly lower than in the controls. After gluten withdrawal there was an improvement towards normality in the responses of blood glucose, serum insulin, and GIP. The results show that untreated coeliac disease is associated with abnormalities of intestinal and pancreatic hormone secretion and that these abnormalities are improved by gluten withdrawal.
对五名未经治疗的乳糜泻患者口服葡萄糖后血浆胃抑制性多肽（GIP）和胰岛素的反应进行了研究。这些患者在无麸质饮食一年后再次接受研究。在未经治疗的患者中，血糖、血清胰岛素和GIP水平显著低于对照组。停止摄入麸质后，血糖、血清胰岛素和GIP的反应向正常水平有所改善。结果表明，未经治疗的乳糜泻与肠道和胰腺激素分泌异常有关，且这些异常通过停止摄入麸质得到改善。
