Beck B, Villaume C, Debry G
Acta Diabetol Lat. 1982 Jan-Mar;19(1):1-11. doi: 10.1007/BF02581180.
The gastric inhibitory polypeptide (GIP) is the main hormone of the incretin type acting on the entero-insular axis. It is released after fat, glucose or meal ingestion. The variations of this secretion are described in obesity and in some pancreatic and gastrointestinal diseases: it is increased in maturity onset diabetes mellitus, obesity or duodenal ulcer, variable according to the food taken and the severity of the pancreatic lesion in chronic pancreatitis and cystic fibrosis, normal in insulinoma and decreased in celiac disease. The impaired absorption of the food-stuffs and the defective feed-back regulation of GIP secretion by insulin are the major causes of these variations. To a lesser degree, gastric acid secretion, gastric emptying and vagal control may also influence GIP secretion.
胃抑肽（GIP）是作用于肠-胰岛轴的主要肠促胰岛素激素。它在摄入脂肪、葡萄糖或食物后释放。这种分泌的变化在肥胖症以及一些胰腺和胃肠道疾病中有所描述：在成年型糖尿病、肥胖症或十二指肠溃疡中增加，在慢性胰腺炎和囊性纤维化中根据所摄入食物和胰腺病变的严重程度而变化，在胰岛素瘤中正常，而在乳糜泻中减少。食物吸收受损以及胰岛素对GIP分泌的反馈调节缺陷是这些变化的主要原因。在较小程度上，胃酸分泌、胃排空和迷走神经控制也可能影响GIP分泌。
