Elsass P, Christensen S E, Ranek L, Theilgaard A, Tygstrup N
Neuropsychological Unit, Neurological Dept., Rigshospitalet, Copenhagen, Denmark.
Scand J Gastroenterol. 1981 Apr;16(3):441-7. doi: 10.3109/00365528109181995.
In 14 patients with encephalopathy due to cirrhosis of the liver levels of consciousness were assessed by clinical ratings and continuous reaction time measurements. The observations were compared with similar measurements made in patients with chronic brain syndrome, patients sedated with diazepam, and hospitalized controls. Patients with hepatic encephalopathy were characterized by having slower reaction times than patients from the other groups. Furthermore, the performance of several liver patients was decreasing during the test. This phenomenon was not seen in the other groups. The continuous reaction times in the liver patients were correlated with the clinical ratings, but the reaction times appeared to be more sensitive, since on several occasions this test became abnormal before the clinical rating. Patients dying within 3 months after the test had more abnormal reaction times than patients surviving this period, indicating a relation between this test and the severity of the liver disease.
对14例肝硬化所致肝性脑病患者，通过临床评分和连续反应时间测量来评估意识水平。将这些观察结果与慢性脑综合征患者、用安定镇静的患者以及住院对照者的类似测量结果进行比较。肝性脑病患者的特点是反应时间比其他组患者慢。此外，部分肝病患者在测试过程中的表现逐渐变差。其他组未出现这种现象。肝病患者的连续反应时间与临床评分相关，但反应时间似乎更敏感，因为在某些情况下，该测试在临床评分出现异常之前就已异常。测试后3个月内死亡的患者比存活患者的反应时间异常更多，表明该测试与肝病严重程度之间存在关联。
