一种卟啉可延长小鼠脑内感染朊病毒后的存活时间。
A porphyrin increases survival time of mice after intracerebral prion infection.
作者信息
Kocisko David A, Caughey Winslow S, Race Richard E, Roper Grant, Caughey Byron, Morrey John D
机构信息
Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 S. 4th Street, Hamilton, MT 59840, USA.
出版信息
Antimicrob Agents Chemother. 2006 Feb;50(2):759-61. doi: 10.1128/AAC.50.2.759-761.2006.
Abstract
Prion diseases, including scrapie, are incurable neurodegenerative disorders. Some compounds can delay disease after a peripheral scrapie inoculation, but few are effective against advanced disease. Here, we tested multiple related porphyrins, but only Fe(III)meso-tetra(4-sulfonatophenyl)porphine injected into mouse brains after intracerebral scrapie inoculation substantially increased survival times.
摘要
朊病毒疾病，包括羊瘙痒症，是无法治愈的神经退行性疾病。一些化合物在外周接种羊瘙痒症后可以延缓疾病进展，但很少有化合物对晚期疾病有效。在此，我们测试了多种相关卟啉，但只有在脑内接种羊瘙痒症后注入小鼠脑内的三价铁中-四(4-磺酸苯基)卟啉能显著延长存活时间。
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