一种卟啉可延长小鼠脑内感染朊病毒后的存活时间。
A porphyrin increases survival time of mice after intracerebral prion infection.
作者信息
Kocisko David A, Caughey Winslow S, Race Richard E, Roper Grant, Caughey Byron, Morrey John D
机构信息
Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 S. 4th Street, Hamilton, MT 59840, USA.
出版信息
Antimicrob Agents Chemother. 2006 Feb;50(2):759-61. doi: 10.1128/AAC.50.2.759-761.2006.
Abstract
Prion diseases, including scrapie, are incurable neurodegenerative disorders. Some compounds can delay disease after a peripheral scrapie inoculation, but few are effective against advanced disease. Here, we tested multiple related porphyrins, but only Fe(III)meso-tetra(4-sulfonatophenyl)porphine injected into mouse brains after intracerebral scrapie inoculation substantially increased survival times.
摘要
朊病毒疾病，包括羊瘙痒症，是无法治愈的神经退行性疾病。一些化合物在外周接种羊瘙痒症后可以延缓疾病进展，但很少有化合物对晚期疾病有效。在此，我们测试了多种相关卟啉，但只有在脑内接种羊瘙痒症后注入小鼠脑内的三价铁中-四(4-磺酸苯基)卟啉能显著延长存活时间。
相似文献
1
A porphyrin increases survival time of mice after intracerebral prion infection.一种卟啉可延长小鼠脑内感染朊病毒后的存活时间。
Antimicrob Agents Chemother. 2006 Feb;50(2):759-61. doi: 10.1128/AAC.50.2.759-761.2006.
2
Enhanced antiscrapie effect using combination drug treatment.联合药物治疗增强抗瘙痒效果。 （注：原文中“antiscrapie”可能有误，推测应为“antipruritic”，若按此推测，译文为“联合药物治疗增强抗瘙痒效果” ，若按原文准确翻译为“增强抗瘙痒效果使用联合药物治疗”，表述较生硬，具体可根据实际情况调整 ）
Antimicrob Agents Chemother. 2006 Oct;50(10):3447-9. doi: 10.1128/AAC.00715-06.
3
The efficacy of tetracyclines in peripheral and intracerebral prion infection.四环素在外周和脑内朊病毒感染中的疗效。
PLoS One. 2008 Mar 26;3(3):e1888. doi: 10.1371/journal.pone.0001888.
4
Prion infection of mouse brain reveals multiple new upregulated genes involved in neuroinflammation or signal transduction.小鼠脑部的朊病毒感染揭示了多个与神经炎症或信号转导相关的新上调基因。
J Virol. 2015 Feb;89(4):2388-404. doi: 10.1128/JVI.02952-14. Epub 2014 Dec 10.
5
Mechanism of the localization of manganese (III) mesotetra(4-sulfonatophenyl)porphine in mice bearing L1210 tumors.中-四(4-磺酸苯基)卟吩锰(III)在携带L1210肿瘤小鼠体内的定位机制
Cancer Lett. 1988 May;40(1):23-32. doi: 10.1016/0304-3835(88)90258-3.
6
RNA-seq and network analysis reveal unique glial gene expression signatures during prion infection.RNA-seq 和网络分析揭示朊病毒感染过程中独特的神经胶质基因表达特征。
Mol Brain. 2020 May 7;13(1):71. doi: 10.1186/s13041-020-00610-8.
7
Mechanistic insights into the cure of prion disease by novel antiprion compounds.新型抗朊病毒化合物治愈朊病毒疾病的机制研究
J Virol. 2007 Oct;81(19):10729-41. doi: 10.1128/JVI.01075-07. Epub 2007 Jul 25.
8
Therapeutic Assay with the Non-toxic C-Terminal Fragment of Tetanus Toxin (TTC) in Transgenic Murine Models of Prion Disease.用破伤风毒素（Tetanus Toxin，TTC）无毒 C 末端片段在朊病毒病转基因鼠模型中进行治疗性分析。
Mol Neurobiol. 2021 Oct;58(10):5312-5326. doi: 10.1007/s12035-021-02489-5. Epub 2021 Jul 20.
9
Marked influence of the route of infection on prion strain apparent phenotype in a scrapie transgenic mouse model.感染途径对朊病毒株在瘙痒转基因小鼠模型中明显表型的显著影响。
Neurobiol Dis. 2011 Jan;41(1):219-25. doi: 10.1016/j.nbd.2010.09.010. Epub 2010 Sep 27.
10
Inability to elicit rapid cytocidal effects on L1210 cells derived from porphyrin-injected mice following in vitro photoirradiation.体外光照射后，对来自卟啉注射小鼠的L1210细胞无法产生快速的细胞杀伤作用。
J Natl Cancer Inst. 1984 Feb;72(2):427-34.
引用本文的文献
1
Combination of Styrylbenzoazole Compound and Hydroxypropyl Methylcellulose Enhances Therapeutic Effect in Prion-Infected Mice.苯并恶唑类化合物与羟丙基甲基纤维素联合应用增强朊病毒感染小鼠的治疗效果。
Mol Neurobiol. 2024 Jul;61(7):4705-4711. doi: 10.1007/s12035-023-03852-4. Epub 2023 Dec 20.
2
A tetracationic porphyrin with dual anti-prion activity.一种具有双重抗朊病毒活性的四价阳离子卟啉。
iScience. 2023 Jul 27;26(9):107480. doi: 10.1016/j.isci.2023.107480. eCollection 2023 Sep 15.
3
Prion therapeutics: Lessons from the past.朊病毒治疗学：过去的经验教训。
Prion. 2022 Dec;16(1):265-294. doi: 10.1080/19336896.2022.2153551.
4
Synthesis and spectral characterization of the first fluorescein-tagged iron(ii) clathrochelates, their supramolecular interactions with globular proteins, and cellular uptake.首例荧光素标记的铁（II）笼形螯合物的合成、光谱表征、它们与球状蛋白的超分子相互作用及细胞摄取
RSC Adv. 2021 Feb 22;11(14):8163-8177. doi: 10.1039/d0ra10502c. eCollection 2021 Feb 17.
5
Multimodal small-molecule screening for human prion protein binders.多模态小分子筛选人类朊病毒蛋白结合物。
J Biol Chem. 2020 Sep 25;295(39):13516-13531. doi: 10.1074/jbc.RA120.014905. Epub 2020 Jul 28.
6
Pharmacological Agents Targeting the Cellular Prion Protein.靶向细胞朊蛋白的药物制剂
Pathogens. 2018 Mar 7;7(1):27. doi: 10.3390/pathogens7010027.
7
Pharmacological chaperone reshapes the energy landscape for folding and aggregation of the prion protein.药理学伴侣重塑了朊病毒蛋白折叠和聚集的能量景观。
Nat Commun. 2016 Jun 27;7:12058. doi: 10.1038/ncomms12058.
8
A cationic tetrapyrrole inhibits toxic activities of the cellular prion protein.一种阳离子四吡咯抑制细胞朊病毒蛋白的毒性活性。
Sci Rep. 2016 Mar 15;6:23180. doi: 10.1038/srep23180.
9
Prion Protein-Hemin Interaction Upregulates Hemoglobin Synthesis: Implications for Cerebral Hemorrhage and Sporadic Creutzfeldt-Jakob Disease.朊病毒蛋白-血红素相互作用上调血红蛋白合成：对脑出血和散发性克雅氏病的影响
J Alzheimers Dis. 2016;51(1):107-21. doi: 10.3233/JAD-151039.
10
Prion protein-coated magnetic beads: synthesis, characterization and development of a new ligands screening method.朊病毒蛋白包被的磁性珠：合成、表征及新型配体筛选方法的开发。
J Chromatogr A. 2015 Jan 30;1379:1-8. doi: 10.1016/j.chroma.2014.12.014. Epub 2014 Dec 12.
本文引用的文献
1
Cerebroventricular infusion of pentosan polysulphate in human variant Creutzfeldt-Jakob disease.在人类变异型克雅氏病中脑室内注入戊聚糖多硫酸盐
J Infect. 2005 Jun;50(5):394-6. doi: 10.1016/j.jinf.2004.07.015.
2
Prion diseases--close to effective therapy?朊病毒疾病——接近有效治疗了吗？
Nat Rev Drug Discov. 2004 Oct;3(10):874-84. doi: 10.1038/nrd1525.
3
Treatment of transmissible spongiform encephalopathy by intraventricular drug infusion in animal models.通过脑室注射药物在动物模型中治疗传染性海绵状脑病。
J Virol. 2004 May;78(10):4999-5006. doi: 10.1128/jvi.78.10.4999-5006.2004.
4
Approaches to prophylaxis and therapy.
Br Med Bull. 2003;66:281-92. doi: 10.1093/bmb/66.1.281.
5
Prophylactic and therapeutic effects of phthalocyanine tetrasulfonate in scrapie-infected mice.四磺酸酞菁对感染羊瘙痒病小鼠的预防和治疗作用。
J Infect Dis. 2003 Sep 1;188(5):699-705. doi: 10.1086/377310. Epub 2003 Aug 14.
6
Tetracyclines affect prion infectivity.四环素会影响朊病毒的传染性。
Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10849-54. doi: 10.1073/pnas.162195499. Epub 2002 Jul 29.
7
Porphyrin and phthalocyanine antiscrapie compounds.卟啉和酞菁抗瘙痒病化合物。
Science. 2000 Feb 25;287(5457):1503-6. doi: 10.1126/science.287.5457.1503.
8
Entry versus blockade of brain infection following oral or intraperitoneal scrapie administration: role of prion protein expression in peripheral nerves and spleen.经口或腹腔注射羊瘙痒病病原体后脑部感染的进入与阻断：朊病毒蛋白在外周神经和脾脏中的表达作用
J Virol. 2000 Jan;74(2):828-33. doi: 10.1128/jvi.74.2.828-833.2000.
9
Prions.朊病毒
Proc Natl Acad Sci U S A. 1998 Nov 10;95(23):13363-83. doi: 10.1073/pnas.95.23.13363.
10
Inhibition of protease-resistant prion protein formation by porphyrins and phthalocyanines.卟啉和酞菁对蛋白酶抗性朊病毒蛋白形成的抑制作用。
Proc Natl Acad Sci U S A. 1998 Oct 13;95(21):12117-22. doi: 10.1073/pnas.95.21.12117.
Zotero 插件