联合药物治疗增强抗瘙痒效果。 （注：原文中“antiscrapie”可能有误，推测应为“antipruritic”，若按此推测，译文为“联合药物治疗增强抗瘙痒效果” ，若按原文准确翻译为“增强抗瘙痒效果使用联合药物治疗”，表述较生硬，具体可根据实际情况调整 ）
Enhanced antiscrapie effect using combination drug treatment.
作者信息
Kocisko David A, Caughey Byron, Morrey John D, Race Richard E
机构信息
Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA.
出版信息
Antimicrob Agents Chemother. 2006 Oct;50(10):3447-9. doi: 10.1128/AAC.00715-06.
Abstract
Combination treatment with pentosan polysulfate and Fe(III)meso-tetra(4-sulfonatophenyl)porphine in mice beginning 14 or 28 days after scrapie inoculation significantly increased survival times. This increase may be synergistic, implying that the compounds act cooperatively in vivo. Combination therapy may therefore be more effective for treatment of transmissible spongiform encephalopathies and other protein-misfolding diseases.
摘要
在小鼠接种羊瘙痒病14天或28天后开始用戊聚糖多硫酸盐和Fe(III)中-四(4-磺基苯基)卟啉进行联合治疗，显著延长了存活时间。这种延长可能具有协同作用，意味着这些化合物在体内协同发挥作用。因此，联合疗法可能对治疗传染性海绵状脑病和其他蛋白质错误折叠疾病更有效。
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