Fiel R J, Mark E, Button T, Gilani S, Musser D
Department of Biophysics, Roswell Park Memorial Institute Buffalo, NY 14263.
Cancer Lett. 1988 May;40(1):23-32. doi: 10.1016/0304-3835(88)90258-3.
In accordance with earlier work the manganese (III) derivative of meso-tetra(4-sulfonatophenyl)porphine (TPPS4) is found to accumulate in the tumors of L1210-bearing mice. The tumor/liver ratio of porphyrin extends from 1.5 to 3.6 over a range of dose and time periods. The subcellular distribution of porphyrin in L1210 tumor and liver, and the tissue distribution (cellular, stroma, soluble) in L1210 tumor indicates that the porphyrin tends to be located predominantly in soluble and stromal fractions. These data are interpreted in terms of the physiology and composition of neoplastic tissue to formalize a mechanism for the localization of Mn(III)TPPS4 in L1210 tumor and a general working hypothesis for the localization of porphyrins in neoplastic tissue. The in vivo stability of Mn(III)TPPS4 is also addressed and is found to be demetallated to a degree of approximately 1% in liver and kidney.
根据早期的研究工作，发现中-四(4-磺酸苯基)卟啉(TPPS4)的锰(III)衍生物在携带L1210肿瘤的小鼠肿瘤中蓄积。在一定剂量和时间段范围内，卟啉的肿瘤/肝脏比率在1.5至3.6之间。L1210肿瘤和肝脏中卟啉的亚细胞分布，以及L1210肿瘤中的组织分布(细胞、基质、可溶性部分)表明，卟啉倾向于主要位于可溶性部分和基质部分。这些数据根据肿瘤组织的生理学和组成进行解释，以形成Mn(III)TPPS4在L1210肿瘤中定位的机制以及卟啉在肿瘤组织中定位的一般工作假设。还研究了Mn(III)TPPS4在体内的稳定性，发现其在肝脏和肾脏中的脱金属程度约为1%。
