吡喹酮和青蒿素衍生物的杀吸虫活性：对成年卡氏棘口吸虫的体外和体内研究
Trematocidal activity of praziquantel and artemisinin derivatives: in vitro and in vivo investigations with adult Echinostoma caproni.
作者信息
Keiser Jennifer, Brun Reto, Fried Bernard, Utzinger Jürg
机构信息
Swiss Tropical Institute, P.O. Box, CH-4002 Basel, Switzerland.
出版信息
Antimicrob Agents Chemother. 2006 Feb;50(2):803-5. doi: 10.1128/AAC.50.2.803-805.2006.
Abstract
We examined the effects of praziquantel and the artemisinins on adult Echinostoma caproni. In vitro, both praziquantel and the artemisinins exhibited exposure-response relationships. In vivo, worm burden reductions of 100% were achieved with single oral doses of praziquantel, artesunate, and artemether at 50, 700, and 1,100 mg/kg of body weight, respectively.
摘要
我们研究了吡喹酮和青蒿素对成年卡氏棘口吸虫的作用。在体外，吡喹酮和青蒿素均呈现暴露-反应关系。在体内，分别给予体重50、700和1100 mg/kg的单次口服剂量吡喹酮、青蒿琥酯和蒿甲醚后，虫体负荷减少了100%。
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