Woodrow C J, Haynes R K, Krishna S
Department of Cellular and Molecular Medicine, Infectious Diseases, St George's Hospital Medical School, Tooting, London, UK.
Postgrad Med J. 2005 Feb;81(952):71-8. doi: 10.1136/pgmj.2004.028399.
Artemisinins were discovered to be highly effective antimalarial drugs shortly after the isolation of the parent artemisinin in 1971 in China. These compounds combine potent, rapid antimalarial activity with a wide therapeutic index and an absence of clinically important resistance. Artemisinin containing regimens meet the urgent need to find effective treatments for multidrug resistant malaria and have recently been advocated for widespread deployment. Comparative trials of artesunate and quinine for severe malaria are in progress to see if the persistently high mortality of this condition can be reduced.
1971年中国分离出青蒿素母体后不久，人们发现青蒿素类药物是高效抗疟药。这些化合物兼具强效、快速的抗疟活性，治疗指数宽且无临床上重要的耐药性。含青蒿素的治疗方案满足了寻找耐多药疟疾有效治疗方法的迫切需求，最近已被提倡广泛应用。青蒿琥酯和奎宁用于治疗重症疟疾的对比试验正在进行，以了解这种疾病持续居高不下的死亡率是否能够降低。
