Eichinger M, Puderbach M, Heussel C-P, Kauczor H-U
Abteilung Radiologie, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg.
Radiologe. 2006 Apr;46(4):275-6, 278-81. doi: 10.1007/s00117-005-1308-9.
Cystic fibrosis (CF) is a multi-systemic disease with major impact on the lungs. Pulmonary manifestation is crucial for the prognosis and life expectancy of patients. Imaging modalities and lung function tests reflect the pulmonary status in these patients. The standard imaging modality for diagnosis and follow-up of pulmonary changes is chest x-ray. The gold standard for the detection of parenchymal lung changes remains high resolution computed tomography (HRCT), but this is not used routinely for CF-patients due to radiation exposure. Magnetic resonance imaging (MRI) used to be of no importance in monitoring cystic fibrosis lung disease, as shown in studies from the 1980s and early 1990 s. The continuing improvement of MRI techniques, however, has allowed for an adequate application of this non-radiation method in diagnosing the major pulmonary findings in CF, in addition to the assessment of lung function.
囊性纤维化(CF)是一种对肺部有重大影响的多系统疾病。肺部表现对患者的预后和预期寿命至关重要。影像学检查和肺功能测试反映了这些患者的肺部状况。用于诊断和随访肺部变化的标准影像学检查是胸部X光。检测肺实质变化的金标准仍然是高分辨率计算机断层扫描(HRCT),但由于辐射暴露,CF患者通常不使用这种检查。如20世纪80年代和90年代初的研究所示,磁共振成像(MRI)过去在监测囊性纤维化肺病方面没有重要作用。然而,随着MRI技术的不断改进,除了评估肺功能外,这种无辐射方法已能够充分应用于诊断CF患者的主要肺部病变。