Tomasi Dardo, Chang Linda, de Castro Caparelli Elisabeth, Telang Frank, Ernst Thomas
Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA.
Ann Neurol. 2006 Feb;59(2):419-23. doi: 10.1002/ana.20766.
Increased acoustic noise (AN) during working memory leads to increased brain activation in healthy individuals and may have greater impact in human immunodeficiency virus (HIV) patients.
Compared with control subjects, HIV patients showed reduced AN activation and lower neuronal marker N-acetylaspartate in prefrontal and parietal cortices. Competing use of the working memory network between AN and cognitive load showed lower dynamic range of the hemodynamic responses in prefrontal and parietal cortices in HIV patients.
These findings suggest that reduced reserve capacity of the working memory network in HIV patients and additional stress (eg, AN) might exhaust the impaired network for more demanding tasks.
在健康个体中，工作记忆期间增加的听觉噪声（AN）会导致大脑激活增加，并且可能对人类免疫缺陷病毒（HIV）患者产生更大影响。
与对照受试者相比，HIV患者在前额叶和顶叶皮质中显示出AN激活减少以及神经元标志物N-乙酰天门冬氨酸水平降低。在HIV患者中，AN与认知负荷之间对工作记忆网络的竞争性使用显示前额叶和顶叶皮质中血液动力学反应的动态范围较低。
这些发现表明，HIV患者工作记忆网络的储备能力降低以及额外的压力（例如AN）可能会使受损的网络因更苛刻的任务而耗尽。
