抽动秽语综合征中脑灰质增加。
Increased midbrain gray matter in Tourette's syndrome.
作者信息
Garraux Gaëtan, Goldfine Andrew, Bohlhalter Stephan, Lerner Alicja, Hanakawa Takashi, Hallett Mark
机构信息
Human Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892-1428, USA.
出版信息
Ann Neurol. 2006 Feb;59(2):381-5. doi: 10.1002/ana.20765.
OBJECTIVE
To investigate cerebral structure in Tourette's syndrome (TS).
METHODS
Voxel-based morphometry study of high-resolution MRIs in 31 TS patients compared with 31 controls.
RESULTS
Increased gray matter mainly in the left mesencephalon in 31 TS patients.
INTERPRETATION
This result constitutes strong and direct evidence supporting Devinsky's hypothesis (Devinsky O. Neuroanatomy of Gilles de la Tourette's syndrome. Possible midbrain involvement. Arch Neurol 1983;40:508-514) according to which midbrain disturbances play an important pathogenic role in TS.
目的
研究抽动秽语综合征（TS）的脑结构。
方法
对31例TS患者的高分辨率磁共振成像进行基于体素的形态学研究，并与31名对照者进行比较。
结果
31例TS患者主要在左中脑出现灰质增加。
解读
这一结果构成了有力的直接证据，支持德温斯基的假说（德温斯基O。抽动秽语综合征的神经解剖学。可能涉及中脑。《神经病学档案》1983年；40:508 - 514），即中脑功能紊乱在TS中起重要的致病作用。
Zotero 插件