高碳酸血症和低碳酸血症对大鼠脑内色氨酸和酪氨酸羟化的影响。

Effect of hypercapnia and hypocapnia on tryptophan and tyrosine hydroxylation in rat brain.

作者信息

Carlsson A, Holmin T, Lindqvist M, Siesjö B K

出版信息

Acta Physiol Scand. 1977 Apr;99(4):503-9. doi: 10.1111/j.1748-1716.1977.tb10404.x.

DOI:10.1111/j.1748-1716.1977.tb10404.x

Abstract

The effects of induced hypo- and hypercapnia upon the rate of hydroxylation of tryptophan and tyrosine in the rat brain were studied by measuring the accumulation of 5-HTP and DOPA following administration of the aromatic L-aminoacid decarboxylase inhibitor 3-hydroxybenzylhydrazine HCl (NSD 1015). The results suggest that the hydroxylation of tryptophan varies directly with the tissue Po2. On the other hand, the hydroxylation of tyrosine did not show a simple relationship to Po2 but appeared to be influenced by pH changes.

摘要

通过测量给予芳香族L-氨基酸脱羧酶抑制剂盐酸3-羟基苄肼（NSD 1015）后5-羟色胺酸（5-HTP）和多巴（DOPA）的蓄积量，研究了诱导性低碳酸血症和高碳酸血症对大鼠脑内色氨酸和酪氨酸羟化速率的影响。结果表明，色氨酸的羟化与组织氧分压直接相关。另一方面，酪氨酸的羟化与氧分压并无简单关系，但其似乎受pH变化的影响。