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氧气:致命还是治病?慢性阻塞性肺疾病患者的院前高氧治疗

Oxygen: kill or cure? Prehospital hyperoxia in the COPD patient.

作者信息

New A

机构信息

East Anglian Ambulance NHS Trust, Hospital Lane, Hellesdon, Norwich NR6 5NA.

出版信息

Emerg Med J. 2006 Feb;23(2):144-6. doi: 10.1136/emj.2005.027458.

DOI:10.1136/emj.2005.027458
PMID:16439751
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2564043/
Abstract

High concentration oxygen therapy has long been a mainstay of prehospital treatment. Guidelines for its administration have for many years also cautioned its use with patients with chronic obstructive pulmonary disease (COPD). Successive guidelines and prehospital textbooks have advocated the use of 28% oxygen masks and re-emphasised the importance of the dangers of hyperoxia, often drawing upon the classic theory of hypoxic drive. Despite this, the reality remains that ambulance crews have tended to overoxygenate such patients. One study demonstrated that 80% of patients sampled with acute exacerbation of their COPD received oxygen in excess of 28% from the ambulance crew. Is this a worrying development or a reassuring sign that prehospital providers are rightly more concerned about the dangers of hypoxia than hyperoxia? And if the guidelines are right, then how are the hearts and minds of ambulance paramedics and technicians won?

摘要

高浓度氧疗长期以来一直是院前治疗的主要手段。多年来,关于其使用的指南也一直告诫要谨慎用于慢性阻塞性肺疾病(COPD)患者。后续的指南和院前急救教材都提倡使用28%氧面罩,并再次强调高氧血症危险的重要性,这往往借鉴了经典的低氧驱动理论。尽管如此,现实情况仍然是,救护人员往往会过度给这类患者吸氧。一项研究表明,80%的慢性阻塞性肺疾病急性加重期抽样患者从救护人员那里接受了超过28%的氧气。这是一个令人担忧的情况,还是一个令人安心的迹象,表明院前急救人员正确地更关注低氧血症而非高氧血症的危险呢?如果指南是正确的,那么如何才能让救护人员和技术人员信服呢?

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本文引用的文献

1
Chronic obstructive pulmonary disease. National clinical guideline on management of chronic obstructive pulmonary disease in adults in primary and secondary care.慢性阻塞性肺疾病。成人慢性阻塞性肺疾病在初级和二级医疗保健中管理的国家临床指南。
Thorax. 2004 Feb;59 Suppl 1(Suppl 1):1-232.
2
Carbon dioxide narcosis in emphysema.肺气肿中的二氧化碳麻醉
Q J Med. 1955 Apr;24(94):155-73.
3
The use of oxygen in acute exacerbations of chronic obstructive pulmonary disease: a prospective audit of pre-hospital and hospital emergency management.慢性阻塞性肺疾病急性加重期氧气的使用:院前及医院急诊管理的前瞻性审计
Clin Med (Lond). 2003 Mar-Apr;3(2):184; author reply 185-6.
4
The use of oxygen in acute exacerbations of chronic obstructive pulmonary disease: a prospective audit of pre-hospital and hospital emergency management.慢性阻塞性肺疾病急性加重期氧气的使用:院前及医院急诊管理的前瞻性审计
Clin Med (Lond). 2003 Mar-Apr;3(2):183-4.
5
The use of oxygen in acute exacerbations of chronic obstructive pulmonary disease: a prospective audit of pre-hospital and hospital emergency management.慢性阻塞性肺疾病急性加重期氧气的使用:院前及医院急诊管理的前瞻性审计
Clin Med (Lond). 2003 Mar-Apr;3(2):183. doi: 10.7861/clinmedicine.3-2-183.
6
The use of oxygen in acute exacerbations of chronic obstructive pulmonary disease: a prospective audit of pre-hospital and hospital emergency management.慢性阻塞性肺疾病急性加重期氧气的使用:院前及医院急诊管理的前瞻性审计
Clin Med (Lond). 2002 Sep-Oct;2(5):449-51. doi: 10.7861/clinmedicine.2-5-449.
7
Emergency oxygen therapy for the breathless patient. Guidelines prepared by North West Oxygen Group.针对呼吸急促患者的紧急氧疗。由西北氧气小组制定的指南。
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8
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9
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Am J Respir Crit Care Med. 2001 Jun;163(7):1755. doi: 10.1164/ajrccm.163.7.16372a.
10
How accurate are pulse oximeters in patients with acute exacerbations of chronic obstructive airways disease?在慢性阻塞性气道疾病急性加重期患者中,脉搏血氧仪的准确性如何?
Respir Med. 2001 May;95(5):336-40. doi: 10.1053/rmed.2001.1046.