Hoggarth Andrew, Waring Mike, Alexander James, Greenwood Amanada, Callaghan Theresa
ConvaTec Wound Therapeutics, Deeside, UK.
Ostomy Wound Manage. 2005 Dec;51(12):30-42.
In the treatment of incontinence dermatitis, a skin protectant primarily prevents skin breakdown due to moisture and biological irritants in urine and feces. To assess the barrier and skin hydration properties of six currently available skin protectants with different formulations, a controlled, three-phase study was conducted at a research facility in the UK among 18 healthy volunteers. The study addressed each product's efficacy against insult from a known irritant (sodium lauryl sulphate), skin hydration potential, and maintenance of skin barrier and barrier efficacy against maceration. Using white petrolatum (glycerin) as the positive control and untreated sites as the negative control, the results show that each one of the products tested has different performance properties. Products containing petrolatum demonstrated protection against irritants (P = 0.006 at 24 hours) and maceration (P < 0.005) and provided some skin hydration. Products containing dimethicone varied in protection against irritants (P < 0.005, or P > or = 0.806 at 24 hours) and have good skin hydration potential and low barrier efficacy (P > 0.500). Zinc oxide-based products showed protection against irritants (P < 0.005) but poor skin hydration and barrier properties to prevent maceration (P = 0.262). Overall, only the water-in-oil petrolatum- based product performed effectively within all the parameters tested. This study suggests that skin barrier protection involves more than the inclusion of an active barrier ingredient. Further testing and use of barrier products in the clinical setting will provide additional evidence for appropriate product selection.
在治疗失禁性皮炎时，皮肤保护剂主要可防止因尿液和粪便中的水分及生物刺激物导致的皮肤破损。为评估六种现有不同配方皮肤保护剂的屏障和皮肤水合特性，在英国一家研究机构对18名健康志愿者进行了一项对照的三阶段研究。该研究考察了每种产品对已知刺激物（月桂醇硫酸酯钠）刺激的疗效、皮肤水合潜力、皮肤屏障的维持以及对浸渍的屏障功效。以白凡士林（甘油）作为阳性对照，未处理部位作为阴性对照，结果表明所测试的每种产品都有不同的性能特性。含凡士林的产品对刺激物有防护作用（24小时时P = 0.006）且能防止浸渍（P < 0.005），并提供一定的皮肤水合作用。含二甲硅油的产品对刺激物的防护作用各异（24小时时P < 0.005，或P≥0.806），具有良好的皮肤水合潜力但屏障功效较低（P > 0.500）。氧化锌基产品对刺激物有防护作用（P < 0.005），但皮肤水合和防止浸渍的屏障性能较差（P = 0.262）。总体而言，只有油包水凡士林基产品在所有测试参数内均表现有效。这项研究表明，皮肤屏障保护所涉及的不仅仅是包含一种活性屏障成分。在临床环境中对屏障产品进行进一步测试和使用将为合适产品的选择提供更多证据。
