Rauschecker H F, Gatzemeier W, Sauer R, Seegenschmiedt M H, Schauer A, Ummenhofer L, Sauerbrei W, Schmoor C, Schumacher M
Chirurgische Universitätsklinik Göttingen.
Chirurg. 1992 Jun;63(6):495-500.
In the German Breast Cancer Study Group (GBSG) multicenter trial "Breast preservation in small breast cancer" 1119 patients were accrued over a period of six years. The study was originally designed as a randomized trial which had to be changed into a prospective observation study. A high therapeutic standard was guaranteed by quality control. The univariate analysis of prognostic variables was the first step to a valid treatment comparison. Those factors determined as being significant were combined with the treatment effects in a multivariate analysis. The published results were obtained after a median observation time of four years.
在德国乳腺癌研究组（GBSG）的多中心试验“小乳腺癌的保乳治疗”中，6年期间共招募了1119例患者。该研究最初设计为一项随机试验，但后来不得不改为前瞻性观察研究。通过质量控制确保了高治疗标准。对预后变量进行单因素分析是进行有效治疗比较的第一步。将确定为有显著意义的因素与多因素分析中的治疗效果相结合。发表的结果是在中位观察时间4年后获得的。
