Gatzemeier W, Schumacher M, Schauer A, Sauer R, Rauschecker H F
Universitätsklinik für Allgemeinchirurgie, Göttingen.
Langenbecks Arch Chir Suppl Kongressbd. 1997;114:1212-4.
In the prospective nonrandomized observation study "Therapy of Small Breast Cancer", which was the first multicenter trial on breast cancer ever conducted in Germany, mastectomy (303 cases) was compared with breast-preservation therapy (733 cases) in patients with stage pT1N0M0 breast cancer. After a median follow-up of 8 years, there is no difference between the treatment modalities with regard to disease-free and overall survival which compares well with the results of international randomized studies. There is no difference in treatment outcome between centers specialized in the therapy of breast diseases in comparison to less experienced institutions as long as a high standard of treatment performance is guaranteed by reference centers.
在德国开展的首个乳腺癌多中心试验——前瞻性非随机观察性研究“小乳腺癌治疗”中，对pT1N0M0期乳腺癌患者的乳房切除术（303例）与保乳治疗（733例）进行了比较。中位随访8年后，两种治疗方式在无病生存率和总生存率方面没有差异，这与国际随机研究的结果相当。只要参考中心保证治疗水平达到高标准，那么与经验较少的机构相比，乳腺疾病治疗专业中心在治疗结果上并无差异。
